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PDPK1 gene

Known as: 3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1, 3-Phosphoinositide Dependent Protein Kinase-1 Gene, 3-phosphoinositide dependent protein kinase 1 
This gene plays a role in cellular signaling and development.
National Institutes of Health

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Related topics

6 relations
3-Phosphoinositide Dependent Protein Kinase-1PDPK1 protein, humanPhosphorylationSerine/Threonine Phosphorylation

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PDPK1 wt Allele

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Inositol Deficiency Increases Neural Tube Defect Susceptibility by PI3K/AKT Signaling Pathway (P11-009-19).
Objectives To explore the possible mechanisms of inositol deficiency in neural tube defects (NTDs). Methods The gas… 
2018
2018
Functional Proteomics and Deep Network Interrogation Reveal a Complex Mechanism of Action of Midostaurin in Lung Cancer Cells*
Phenotypic drug screening identified the clinical PKC inhibitor midostaurin to have potent activity in several lung cancer cells… 
2018
2018
miR-718 is involved in malignancy of papillary thyroid cancer through repression of PDPK1.
2018
2018
A new and important relationship between miRNA‐147a and PDPK1 in radiotherapy
It was found that the expression level of miR‐147a was significantly increased and the pathway of PI3K/AKT was dramatically… 
2017
2017
Abstract P3-03-05: PI3K/PDK1 mediates resistance to CDK4/6 inhibitors through dysregulation of S-phase cyclins/cyclin dependent kinases (CDKs)
Background: CDK4/6 inhibitors in combination with antiestrogens are approved for the treatment of ER+ advanced breast cancer… 
2016
2016
Abstract PD2-06: Inhibition of 3-phosphoinositide dependent protein kinase 1 (PDK1) synergizes with CDK4/6 inhibitors against ER-positive breast cancer
Background: Dysregulation in cell cycle checkpoints is common in cancer. Small molecule inhibitors that target the CDK4/6… 
2015
2015
MicroRNA profiling identifies miR-129-5p as a regulator of EMT in tubular epithelial cells.
The importance of microRNAs in various diseases has been demonstrated, but their potential role in the pathogenesis of renal… 
2015
2015
Abstract 1754: BPR2P001S0, a Coumarin derivative, induced cell cycle arrest in A549 through inhibiting PDPK1 activity
Lung cancer is one of the most common causes of cancer deaths in the world, and the emergence of resistant lung cancer cells can… 
2011
2011
Abstract 4481: Topical application of the dual PDPK1/AKT inhibitor PHT-427 inhibits signaling and growth of human breast cancer cutaneous metastases in mice
Proceedings: AACR 102nd Annual Meeting 2011‐‐ Apr 2‐6, 2011; Orlando, FL Despite advances in the treatment of breast cancer… 
2006
2006
Zinc as an insulin replacement in hybridoma cultures.
There are many advantages to the use of protein-free media for biologics production, including a reduced risk of viral… 
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