PD 98059

Known as: PD-098059, PD98059, PD09859 
A cell-permeable, selective mitogen-activated protein (MAP) kinase inhibitor which exhibits activity through the inhibition of the phosphorylation… (More)
National Institutes of Health

Papers overview

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Highly Cited
2001
Highly Cited
2001
Minocycline, a semisynthetic tetracycline derivative, protects brain against global and focal ischemia in rodents. We examined… (More)
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Highly Cited
2000
Highly Cited
2000
The specificities of 28 commercially available compounds reported to be relatively selective inhibitors of particular serine… (More)
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Highly Cited
1998
Highly Cited
1998
The kinase inhibitors SB 203580 and PD 98059 have been reported to be specific inhibitors of the 38- and 42/44-kDa mitogen… (More)
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Highly Cited
1998
Highly Cited
1998
IL-17 is a newly described, T cell-derived cytokine with ill-defined physiologic properties. As such, we examined the release of… (More)
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Highly Cited
1998
Highly Cited
1998
We have identified a novel mitogen- and stress-activated protein kinase (MSK1) that contains two protein kinase domains in a… (More)
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Highly Cited
1998
Highly Cited
1998
The compound U0126 (1,4-diamino-2,3-dicyano-1, 4-bis[2-aminophenylthio]butadiene) was identified as an inhibitor of AP-1… (More)
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Highly Cited
1998
Highly Cited
1998
Angiotensin II induces an oxidant stress-dependent hypertrophy in cultured vascular smooth muscle cells. To investigate the… (More)
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Highly Cited
1997
Highly Cited
1997
It is well established that mitogens inhibit differentiation of skeletal muscle cells, but the insulin-like growth factors (IGFs… (More)
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Highly Cited
1995
Highly Cited
1995
PD 098059 has been shown previously to inhibit the dephosphorylated form of mitogen-activated protein kinase kinase-1 (MAPKK1… (More)
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Highly Cited
1995
Highly Cited
1995
Treatment of cells with a variety of growth factors triggers a phosphorylation cascade that leads to activation of mitogen… (More)
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