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PD 98059

Known as: PD-098059, PD98059, PD09859 
A cell-permeable, selective mitogen-activated protein (MAP) kinase inhibitor which exhibits activity through the inhibition of the phosphorylation… 
National Institutes of Health

Papers overview

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Review
2006
Review
2006
MAPK signalling: ERK5 versus ERK1/2
Extracellular‐signal‐regulated kinase 5 (ERK5) is a member of the mitogen‐activated protein kinase (MAPK) family and, similar to… 
Highly Cited
2005
Highly Cited
2005
ERK is sequentially activated in neurons, microglia, and astrocytes by spinal nerve ligation and contributes to mechanical allodynia in this neuropathic pain model
Highly Cited
2004
Highly Cited
2004
Oxidative stress inhibits osteoblastic differentiation of bone cells by ERK and NF-kappaB.
Highly Cited
2003
Highly Cited
2003
The Antimicrobial Peptide LL-37 Activates Innate Immunity at the Airway Epithelial Surface by Transactivation of the Epidermal Growth Factor Receptor 1
Antimicrobial peptides produced by epithelial cells and neutrophils represent essential elements of innate immunity, and include… 
Highly Cited
2002
Highly Cited
2002
Lipopolysaccharide-mediated Reactive Oxygen Species and Signal Transduction in the Regulation of Interleukin-1 Gene Expression*
Lipopolysaccharide (LPS) stimulates macrophages to release inflammatory cytokines, interleukin-1β (IL-1), and tumor necrosis… 
Highly Cited
2001
Highly Cited
2001
Anti-apoptotic signaling by hepatocyte growth factor/Met via the phosphatidylinositol 3-kinase/Akt and mitogen-activated protein kinase pathways.
Hepatocyte growth factor (HGF) is a ligand of the receptor tyrosine kinase encoded by the c-Met protooncogene. HGF/Met signaling… 
Highly Cited
1999
Highly Cited
1999
Suppression of SHP-2 and ERK signalling promotes self-renewal of mouse embryonic stem cells.
The propagation of pluripotent mouse embryonic stem (ES) cells depends on signals transduced through the cytokine receptor… 
Highly Cited
1998
Highly Cited
1998
p38 Mitogen-activated Protein Kinase Is a Critical Component of the Redox-sensitive Signaling Pathways Activated by Angiotensin II
Angiotensin II induces an oxidant stress-dependent hypertrophy in cultured vascular smooth muscle cells. To investigate the… 
Highly Cited
1997
Highly Cited
1997
Conditional Expression of the Mitogen-activated Protein Kinase (MAPK) Phosphatase MKP-1 Preferentially Inhibits p38 MAPK and Stress-activated Protein Kinase in U937 Cells*
Phorbol ester tumor promoters, such as phorbol 12-myristate 13-acetate (PMA), are potent activators of extracellular signal… 
Highly Cited
1997
Highly Cited
1997
Cardiotrophin 1 (CT-1) Inhibition of Cardiac Myocyte Apoptosis via a Mitogen-activated Protein Kinase-dependent Pathway
Cardiac myocyte survival is of central importance in the maintenance of the function of heart, as well as in the development of a… 
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