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PD 98059

Known as: PD-098059, PD98059, PD09859 
A cell-permeable, selective mitogen-activated protein (MAP) kinase inhibitor which exhibits activity through the inhibition of the phosphorylation… 
National Institutes of Health

Papers overview

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Highly Cited
2002
Highly Cited
2002
FGF-2 and TPA induce matrix metalloproteinase-9 secretion in MCF-7 cells through PKC activation of the Ras/ERK pathway.
Highly Cited
2001
Highly Cited
2001
Role of STAT3 and PI 3-Kinase/Akt in Mediating the Survival Actions of Cytokines on Sensory Neurons
The binding of cytokines to the gp130 receptor activates the STAT3, MEK/MAPK, and PI3K/Akt signalling pathways. To assess the… 
Highly Cited
2001
Highly Cited
2001
Ouabain-induced Signaling and Vascular Smooth Muscle Cell Proliferation*
The hypothesis of this study is that the sodium pump complex acts as an intracellular signal-transducing molecule in canine… 
Highly Cited
2000
Highly Cited
2000
PD98059 Prevents Neurite Degeneration Induced by Fibrillar β‐Amyloid in Mature Hippocampal Neurons
Abstract: How senile plaques and neurofibrillary tangles are linked represents a major gap in our understanding of the… 
Highly Cited
2000
Highly Cited
2000
Interleukin-6-induced STAT3 transactivation and Ser727 phosphorylation involves Vav, Rac-1 and the kinase SEK-1/MKK-4 as signal transduction components.
In the present study, signal transducer and activator of transcription 3 (STAT3) Ser(727) phosphorylation and transactivation was… 
Highly Cited
1999
Highly Cited
1999
Neurotrophin-3 Contributes to the Initiation of Behavioral Sensitization to Cocaine by Activating the Ras/Mitogen-Activated Protein Kinase Signal Transduction Cascade
These experiments were designed to assess the role of neurotrophins and the Ras/mitogen-activated protein kinase (MAP) signal… 
Highly Cited
1998
Highly Cited
1998
Inhibition of the mitogen activated protein (MAP) kinase cascade potentiates cell killing by low dose ionizing radiation in A431 human squamous carcinoma cells
The molecular mechanism(s) by which tumor cells survive after exposure to ionizing radiation are not fully understood. Exposure… 
Highly Cited
1998
Highly Cited
1998
Insulin-like growth factor-I prevents apoptosis in neurons after nerve growth factor withdrawal.
Insulin-like growth factor-I (IGF-I) is emerging as an important growth factor able to modulate the programmed cell death (PCD… 
Highly Cited
1997
Highly Cited
1997
Sustained Activation of the Extracellular Signal-regulated Kinase/Mitogen-activated Protein Kinase Pathway Is Required for Megakaryocytic Differentiation of K562 Cells*
The extracellular signal-regulated kinase (ERK), originally identified as a participant in mitogenic signaling, has recently been… 
Highly Cited
1997
Highly Cited
1997
Regulation of Mitogen-activated Protein Kinase Phosphatase-1 Expression by Extracellular Signal-related Kinase-dependent and Ca2+-dependent Signal Pathways in Rat-1 Cells*
Stimulation of Rat-1 cells with lysophosphatidic acid (LPA) or epidermal growth factor (EGF) results in a biphasic, sustained… 
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