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PD 98059

Known as: PD-098059, PD98059, PD09859 
A cell-permeable, selective mitogen-activated protein (MAP) kinase inhibitor which exhibits activity through the inhibition of the phosphorylation… Expand
National Institutes of Health

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Highly Cited
2003
Highly Cited
2003
Nuclear factor κB (NF‐κB) is one of the key regulators of transcription of a variety of genes involved in immune and inflammatory… Expand
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Highly Cited
2001
Highly Cited
2001
Minocycline, a semisynthetic tetracycline derivative, protects brain against global and focal ischemia in rodents. We examined… Expand
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Highly Cited
2000
Highly Cited
2000
The specificities of 28 commercially available compounds reported to be relatively selective inhibitors of particular serine… Expand
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Highly Cited
1998
Highly Cited
1998
The compound U0126 (1,4-diamino-2,3-dicyano-1,4-bis[2-aminophenylthio]butadiene) was identified as an inhibitor of AP-1… Expand
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Highly Cited
1998
Highly Cited
1998
IL-17 is a newly described, T cell-derived cytokine with ill-defined physiologic properties. As such, we examined the release of… Expand
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Highly Cited
1998
Highly Cited
1998
The mammalian response to stress is complex, often involving multiple signalling pathways that act in concert to influence cell… Expand
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Highly Cited
1997
Highly Cited
1997
Vascular endothelial growth factor (VEGF) is a potent chemotactic agent for endothelial cells. Yet the signalling pathways that… Expand
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Highly Cited
1995
Highly Cited
1995
PD 098059 has been shown previously to inhibit the dephosphorylated form of mitogen-activated protein kinase kinase-1 (MAPKK1… Expand
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Highly Cited
1995
Highly Cited
1995
Treatment of cells with a variety of growth factors triggers a phosphorylation cascade that leads to activation of mitogen… Expand
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Highly Cited
1995
Highly Cited
1995
The mitogen-activated protein kinase (MAP kinase) pathway is thought to play an important role in the actions of neurotrophins. A… Expand
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