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C-terminal modifications regulate MDM2 dissociation and nuclear export of p53
p53 functions to prevent malignant progression, in part by inhibiting proliferation or inducing the death of potential tumour cells. One of the most important regulators of p53 is MDM2, a RING domainExpand
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The Met Receptor Degradation Pathway
Acute stimulation of the receptor for the hepatocyte growth factor/scatter factor Met leads to receptor monoubiquitination and down-regulation through the lysosomal degradation pathway. We haveExpand
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The utility of the ISAC allergen array in the investigation of idiopathic anaphylaxis
A diagnosis of idiopathic anaphylaxis following a detailed clinical assessment remains very challenging for patients and clinicians. Risk reduction strategies such as allergen avoidance are notExpand
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Isolation of Stool-Derived Mucus Provides a High Yield of Colonocytes Suitable for Early Detection of Colorectal Carcinoma
Background: Promising stool-based screening tests for colorectal carcinoma (CRC) rely on detection of exfoliated colonocytes or their contents. However, methods of colonocyte retrieval have not beenExpand
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Roles for basal and stimulated p21(Cip-1/WAF1/MDA6) expression and mitogen-activated protein kinase signaling in radiation-induced cell cycle checkpoint control in carcinoma cells.
We investigated the role of the cdk inhibitor protein p21(Cip-1/WAF1/MDA6) (p21) in the ability of MAPK pathway inhibition to enhance radiation-induced apoptosis in A431 squamous carcinoma cells. InExpand
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Cytogenetics caseload survey summary 2012.
In 2004 a cytogenetics caseload and FTE survey was conducted to evaluate cytogenetic laboratory casELoad and full-time employee equivalent (FTE) statistics. Expand
The Nunclon Sphera surface supports formation of three dimensional cancer spheroids in suspension
While monolayer cell culture has been used extensively to study many types of cancers in vitro, 3 dimensional (3D) cultures of cancer spheroids better simulate the in vivo environment and, thereforeExpand