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PD 158780

Known as: PD-158780, PD158780 
National Institutes of Health

Papers overview

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Highly Cited
2005
Highly Cited
2005
Activation of the neuregulin-1/ErbB signaling pathway promotes the proliferation of neoplastic Schwann cells in human malignant peripheral nerve sheath tumors
Patients with neurofibromatosis type 1 develop aggressive Schwann cell neoplasms known as malignant peripheral nerve sheath… 
Highly Cited
2005
Highly Cited
2005
Insulin receptor substrate is a mediator of phosphoinositide 3-kinase activation in quiescent pancreatic cancer cells.
Phosphoinositide 3-kinase (PI3K) is activated in pancreatic cancer cells and plays a central role in their proliferation… 
2004
2004
Constitutive Activation of the Neuregulin-1/erbB Signaling Pathway Promotes the Proliferation of a Human Peripheral Neuroepithelioma Cell Line
Neuregulin-1 (NRG-1) proteins, acting through their erbB receptors, promote the differentiation, survival and/or proliferation of… 
2004
2004
G1 cell cycle arrest due to the inhibition of erbB family receptor tyrosine kinases does not require the retinoblastoma protein.
2003
2003
Neuregulin-1β modulates in vivo entorhinal–hippocampal synaptic transmission in adult rats
2003
2003
Constitutive activation of the neuregulin‐1/ErbB receptor signaling pathway is essential for the proliferation of a neoplastic Schwann cell line
Neuregulin‐1 (NRG‐1) proteins promote Schwann cell survival, differentiation and proliferation during development. High levels of… 
2003
2003
Dissociation of focal adhesion kinase and paxillin tyrosine phosphorylation induced by bombesin and lysophosphatidic acid from epidermal growth factor receptor transactivation in Swiss 3T3 cells
Tyrosine phosphorylation of the nonreceptor tyrosine kinase p125 focal adhesion kinase (FAK) and the adapter protein paxillin is… 
2002
2002
Metalloproteinases Stimulate ErbB-dependent ERK Signaling in Human Skin Organ Culture*
To investigate the role of ERK signaling in human skin responses to wounding, organ cultures of human skin were maintained for 0… 
1999
1999
Growth inhibition of nasopharyngeal carcinoma cells by EGF receptor tyrosine kinase inhibitors.
Nasopharyngeal carcinoma (NPC) is a malignancy of epithelial origin occurring with a high incidence in southern China and… 
1997
1997
The epidermal growth factor receptor is not required for tumor necrosis factor-alpha action in normal mammary epithelial cells.
Our laboratory has shown that tumor necrosis factor-alpha (TNF alpha) can regulate normal mammary epithelial cell (MEC) growth… 
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