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Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity
TLDR
A meta-analysis of genome-wide association studies and independent data sets genotyped on the Immunochip identified 15 new susceptibility loci, increasing to 36 the number associated with psoriasis in European individuals, and identified five independent signals within previously known loci. Expand
Rare and common variants in CARD14, encoding an epidermal regulator of NF-kappaB, in psoriasis.
TLDR
Fifteen additional rare missense variants in CARD14 are described, their distribution in seven psoriasis cohorts, and their effects on NF-kB activation and the transcriptome of keratinocytes, to contribute to the understanding of the genetic basis of Psoriasis and illustrate the challenges faced in identifying pathogenic variants in common disease. Expand
Genomewide Scan Reveals Association of Psoriasis with IL-23 and NF-κB Pathways
TLDR
The results provide strong support for the association of at least seven genetic loci and psoriasis (each with combined P < 5 × 10−8) and suggest priority targets for study in other auto-immune disorders. Expand
Evidence for two psoriasis susceptibility loci (HLA and 17q) and two novel candidate regions (16q and 20p) by genome-wide scan.
TLDR
This genome-wide scan identifies a psoriasis susceptibility locus at HLA, confirms linkage to 17q, and recommends two novel genomic regions for further scrutiny, one of these regions (16q) overlaps with a recently-identified susceptibility loci for Crohn's disease. Expand
Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci
TLDR
The COMorbidities among the five immune diseases were best explained by biological pleiotropy rather than heterogeneity (a subgroup of cases genetically identical to those with another disease, possibly owing to diagnostic misclassification, molecular subtypes or excessive comorbidity), and the strong comor bid between primary sclerosing cholangitis and inflammatory bowel disease is likely the result of a unique disease. Expand
Sequence and haplotype analysis supports HLA-C as the psoriasis susceptibility 1 gene.
TLDR
Results strongly suggest that HLA-Cw6 is the PSORS1 risk allele that confers susceptibility to early-onset psoriasis. Expand
Genome-wide association study identifies a psoriasis susceptibility locus at TRAF3IP2
TLDR
A genome-wide association analysis of 2,339,118 SNPs in 472 PsV cases and 1,146 controls from Germany suggests that TRAF3IP2 represents a shared susceptibility for PsV and PsA. Expand
Deletion of the late cornified envelope LCE3B and LCE3C genes as a susceptibility factor for psoriasis
TLDR
LCE expression can be induced in normal epidermis by skin barrier disruption and is strongly expressed in psoriatic lesions, suggesting that compromised skin barrier function has a role in psoriasis susceptibility. Expand
Pervasive Sharing of Genetic Effects in Autoimmune Disease
TLDR
Evidence that 47/107 immune-mediated disease risk SNPs are associated to multiple—but not all—immune-mediated diseases is found and distinct groups of interacting proteins are encoded near SNPs which predispose to the same subsets of diseases are proposed as the mechanistic basis of shared disease risk. Expand
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