Genomewide Scan Reveals Association of Psoriasis with IL-23 and NF-κB Pathways
The results provide strong support for the association of at least seven genetic loci and psoriasis (each with combined P < 5 × 10−8) and suggest priority targets for study in other auto-immune disorders.
Rare and common variants in CARD14, encoding an epidermal regulator of NF-kappaB, in psoriasis.
Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci
The COMorbidities among the five immune diseases were best explained by biological pleiotropy rather than heterogeneity (a subgroup of cases genetically identical to those with another disease, possibly owing to diagnostic misclassification, molecular subtypes or excessive comorbidity), and the strong comor bid between primary sclerosing cholangitis and inflammatory bowel disease is likely the result of a unique disease.
Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity
A meta-analysis of genome-wide association studies and independent data sets genotyped on the Immunochip identified 15 new susceptibility loci, increasing to 36 the number associated with psoriasis in European individuals, and identified five independent signals within previously known loci.
Evidence for two psoriasis susceptibility loci (HLA and 17q) and two novel candidate regions (16q and 20p) by genome-wide scan.
This genome-wide scan identifies a psoriasis susceptibility locus at HLA, confirms linkage to 17q, and recommends two novel genomic regions for further scrutiny, one of these regions (16q) overlaps with a recently-identified susceptibility loci for Crohn's disease.
Sequence and haplotype analysis supports HLA-C as the psoriasis susceptibility 1 gene.
Results strongly suggest that HLA-Cw6 is the PSORS1 risk allele that confers susceptibility to early-onset psoriasis.
Genome-wide association study identifies a psoriasis susceptibility locus at TRAF3IP2
A genome-wide association analysis of 2,339,118 SNPs in 472 PsV cases and 1,146 controls from Germany suggests that TRAF3IP2 represents a shared susceptibility for PsV and PsA.
Induction of IL-17+ T Cell Trafficking and Development by IFN-γ: Mechanism and Pathological Relevance in Psoriasis1
A novel mechanistic interaction between Th1 and IL-17+ T cells is revealed, the view that Th1 cells suppress Th17 development through IFN-γ is challenged, and it is suggested that Th4+ and CD8+ IL- 17+ T cell in skin lesions of psoriasis may collaboratively contribute to human autoimmune diseases.
Deletion of the late cornified envelope LCE3B and LCE3C genes as a susceptibility factor for psoriasis
LCE expression can be induced in normal epidermis by skin barrier disruption and is strongly expressed in psoriatic lesions, suggesting that compromised skin barrier function has a role in psoriasis susceptibility.
Transcriptome analysis of psoriasis in a large case-control sample: RNA-seq provides insights into disease mechanisms
The power of WGCNA to elucidate gene regulatory circuits in psoriasis, and emphasize the influence of tissue architecture in both differential expression and co-expression analysis, is demonstrated.