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PD 153035

Known as: PD-153035, PD153035 
National Institutes of Health

Papers overview

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Highly Cited
2009
Highly Cited
2009
EGFR Tyrosine Kinase Inhibitor (PD153035) Improves Glucose Tolerance and Insulin Action in High-Fat Diet–Fed Mice
OBJECTIVE In obesity, an increased macrophage infiltration in adipose tissue occurs, contributing to low-grade inflammation and… 
Highly Cited
2007
Highly Cited
2007
Control of tight junctional sealing: role of epidermal growth factor.
Epithelia can adjust the permeability of their paracellular permeation route to physiological requirements, pathological… 
Highly Cited
2006
Highly Cited
2006
Prostaglandin E2 receptor EP1 transactivates EGFR/MET receptor tyrosine kinases and enhances invasiveness in human hepatocellular carcinoma cells
Recent evidence indicates that cyclooxygenase‐2 (COX‐2) and epidermal growth factor receptor (EGFR) are involved in… 
Highly Cited
2005
Highly Cited
2005
Targeted inhibition of transient activation of the EGFR-mediated cell survival pathway enhances paclitaxel-induced ovarian cancer cell death.
Emerging studies have suggested that transient activation of the cell survival pathway may be the strategy for cancer cells to… 
Highly Cited
2002
Highly Cited
2002
Leukotriene D(4) activates MAPK through a Ras-independent but PKCepsilon-dependent pathway in intestinal epithelial cells.
We have recently shown that leukotriene D(4) (LTD(4)) increases cell survival in intestinal epithelial cells. Here we report and… 
Highly Cited
2002
Highly Cited
2002
Regulation of Akt by EGF-R inhibitors, a possible mechanism of EGF-R inhibitor-enhanced TRAIL-induced apoptosis.
2002
2002
ACTIVATION OF EGF RECEPTORS MEDIATES PULMONARY VASOCONSTRICTION INDUCED BY RESIDUAL OIL FLY ASH
Residual oil fly ash (ROFA)is a constituent of pollutant particles that can producelung injury and activate protein tyrosine… 
Highly Cited
2001
Highly Cited
2001
Loss of focal adhesion kinase (FAK) inhibits epidermal growth factor receptor-dependent migration and induces aggregation of nh(2)-terminal FAK in the nuclei of apoptotic glioblastoma cells.
In glioblastoma cells, inhibition of focal adhesion kinase (FAK) by the focal adhesion targeting domain attenuated epidermal… 
2001
2001
Transmodulation of epidermal growth factor receptor mediates IL-1 beta-induced MMP-1 expression in cultured human keratinocytes.
Ultraviolet (UV) irradiation causes human skin aging and skin cancer through the activation of matrix metalloproteinases (MMPs… 
Highly Cited
1999
Highly Cited
1999
Elevation of the epidermal growth factor receptor and dependent signaling in human papillomavirus-infected laryngeal papillomas.
Laryngeal papillomas are benign tumors caused by human papillomaviruses types 6 and 11. This study addressed alterations in… 
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