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Cyclooxygenase‐2 promotes hepatocellular carcinoma cell growth through AKT activation: Evidence for AKT inhibition in celecoxib‐induced apoptosis
The results suggest the involvement of COX‐2‐dependent and ‐independent mechanisms in celecoxib‐mediated HCC cell apoptosis. Expand
R-2HG Exhibits Anti-tumor Activity by Targeting FTO/m6A/MYC/CEBPA Signaling
While R-2HG accumulated in IDH1/2 mutant cancers contributes to cancer initiation, this work demonstrates anti-tumor effects of 2HG in inhibiting proliferation/survival of FTO-high cancer cells via targeting FTO/m6A/MYC/CEBPA signaling. Expand
The Omega-3 Polyunsaturated Fatty Acid DHA Induces Simultaneous Apoptosis and Autophagy via Mitochondrial ROS-Mediated Akt-mTOR Signaling in Prostate Cancer Cells Expressing Mutant p53
Results show that, in addition to apoptosis, DHA increased the expression levels of lipidated form LC3B and potently stimulated the autophagic flux, suggesting that DHA induces both autophagy and apoptosis in cancer cells expressing mutant p53. Expand
Liver-specific deletion of augmenter of liver regeneration accelerates development of steatohepatitis and hepatocellular carcinoma in mice.
Mice developed with liver-specific deletion of ALR showed that it is required for mitochondrial function and lipid homeostasis in the liver, and provide a useful model for investigating the pathogenesis of steatohepatitis and its complications. Expand
miR-17-92 cluster promotes cholangiocarcinoma growth: evidence for PTEN as downstream target and IL-6/Stat3 as upstream activator.
It is observed that the expression of the miR-17-92 cluster is regulated by IL-6/Stat3, a key oncogenic signaling pathway pivotal in cholangiocarcinogenesis and tumor progression. Expand
Cyclooxygenase-2-derived prostaglandin E2 activates beta-catenin in human cholangiocarcinoma cells: evidence for inhibition of these signaling pathways by omega 3 polyunsaturated fatty acids.
It is suggested that omega 3-PUFAs block cholangiocarcinoma cell growth at least in part through inhibition of Wnt/beta-catenin and COX-2 signaling pathways. Expand
Cyclooxygenase-2 in hepatocellular carcinoma.
  • Tong Wu
  • Medicine
  • Cancer treatment reviews
  • 1 February 2006
This review summarizes the recent advances in understanding the mechanisms for COX-2-derived PG signaling in hepatocarcinogenesis and focuses on the newly unveiled interactions between PG cascade and other key signaling pathways that coordinately regulate HCC growth. Expand
Docosahexaenoic acid induces autophagy through p53/AMPK/mTOR signaling and promotes apoptosis in human cancer cells harboring wild-type p53
It is demonstrated that autophagy contributes to the cytotoxicity of DHA in cancer cells harboring wild-type p53, and compelling evidence for the interplay betweenAutophagy and apoptosis induced by DHA is supported by the findings that Autophagy inhibition suppressed apoptosis and further autophagic induction enhanced apoptosis in response to DHA treatment. Expand
Omega-3 polyunsaturated fatty acids inhibit hepatocellular carcinoma cell growth through blocking β-catenin and cyclooxygenase-2
It is reported that ω-3 polyunsaturated fatty acids (PUFA), docosahexaenoic acid (DHA), and eicosapentaenoic acids (EPA) inhibit HCC growth through simultaneously inhibition of COX-2 and β-catenin. Expand
HCV infection selectively impairs type I but not type III IFN signaling.
It is indicated that HCV induces ER stress and that the autophagy response selectively impairs type I (but not type III) IFN signaling, which explains why IFN-λ ( but notIFN-α) produced a sustained antiviral response against HCV. Expand