Elevation of the epidermal growth factor receptor and dependent signaling in human papillomavirus-infected laryngeal papillomas.

@article{Johnston1999ElevationOT,
  title={Elevation of the epidermal growth factor receptor and dependent signaling in human papillomavirus-infected laryngeal papillomas.},
  author={Derrick Johnston and H{\aa}kan T L Hall and Teresa P DiLorenzo and Bettie M. Steinberg},
  journal={Cancer research},
  year={1999},
  volume={59 4},
  pages={968-74}
}
Laryngeal papillomas are benign tumors caused by human papillomaviruses types 6 and 11. This study addressed alterations in levels of signal transduction from the epidermal growth factor receptor (EGFR) in papillomas and cultured papilloma cells compared to normal tissue and cells. Mitogen-activated protein kinase (MAPK) was activated to a greater extent, phosphotyrosine was more abundant, and EGFR was overexpressed in laryngeal papillomas compared to normal laryngeal epithelium by Western blot… CONTINUE READING

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EGFR protein, humanGene product plays role in biological processSignal Transduction
This study addressed alterations in levels of signal transduction from the epidermal growth factor receptor ( EGFR ) in papillomas and cultured papilloma cells compared to normal tissue and cells .
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