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PCLO protein, human

Known as: aczonin protein, human, Aczonin, Protein Piccolo 
Protein piccolo (5065 aa, ~553 kDa) is encoded by the human PCLO gene. This protein is involved in the structure and function of neuronal synapses.
National Institutes of Health

Related topics

Related topics

12 relations
C2 DomainsCalcium BindingCalcium-Binding ProteinsCytoskeletal Modeling

Broader (2)

Cytoskeletal ProteinsNeuropeptides

Papers overview

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Highly Cited
2016
Highly Cited
2016
Dual-color STED microscopy reveals a sandwich structure of Bassoon and Piccolo in active zones of adult and aged mice
Presynaptic active zones play a pivotal role as synaptic vesicle release sites for synaptic transmission, but the molecular… 
Review
2015
Review
2015
Analytical performance of the Abaxis Piccolo Xpress® point of care analyzer in whole blood, serum, and plasma.
Highly Cited
2011
Highly Cited
2011
Molecular in situ topology of Aczonin/Piccolo and associated proteins at the mammalian neurotransmitter release site
The protein machinery of neurotransmitter exocytosis requires efficient orchestration in space and time, for speed and precision… 
2010
2010
Piccolo knockdown-induced impairments of spatial learning and long-term potentiation in the hippocampal CA1 region
Highly Cited
2009
Highly Cited
2009
Dynein light chain regulates axonal trafficking and synaptic levels of Bassoon
Bassoon and the related protein Piccolo are core components of the presynaptic cytomatrix at the active zone of neurotransmitter… 
Review
2006
Review
2006
Molecular organization of the presynaptic active zone
The exocytosis of neurotransmitter-filled synaptic vesicles is under tight temporal and spatial control in presynaptic nerve… 
Highly Cited
2004
Highly Cited
2004
A conformational switch in the Piccolo C2A domain regulated by alternative splicing
C2 domains are widespread Ca2+-binding modules. The active zone protein Piccolo (also known as Aczonin) contains an unusual C2A… 
Highly Cited
2001
Highly Cited
2001
An unusual C2‐domain in the active‐zone protein piccolo: implications for Ca2+ regulation of neurotransmitter release
Ca2+ regulation of neurotransmitter release is thought to require multiple Ca2+ sensors with distinct affinities. However, no low… 
Review
2000
Review
2000
Molecular determinants of presynaptic active zones
Highly Cited
1999
Highly Cited
1999
Aczonin, a 550-Kd Putative Scaffolding Protein of Presynaptic Active Zones, Shares Homology Regions with Rim and Bassoon and Binds Profilin
Neurotransmitter exocytosis is restricted to the active zone, a specialized area of the presynaptic plasma membrane. We report… 
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