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Physical Performance and Frailty in Chronic Kidney Disease
TLDR
CKD severity was associated with poor physical performance and frailty in a graded fashion and future trials should determine if outcomes for CKD patients with frailty andpoor physical performance are improved by targeted interventions. Expand
A cross-sectional study of vitamin D and insulin resistance in children
TLDR
Low 25-OH-D, common in the paediatric population at risk for diabetes (older children, African–Americans, children with increasing BMI-Z) is associated with worse insulin resistance. Expand
Development and validation of a turbulent flow chromatography and tandem mass spectrometry method for the quantitation of methotrexate and its metabolites 7-hydroxy methotrexate and DAMPA in serum.
TLDR
The TFC-LC-MS/MS MTX method was compared with three other clinically validated MTX assays: a dihydrofolate reductase (DHFR) inhibition assay, an immunoassay based on fluorescence polarization and a previously developed LC- MS/MS assay. Expand
Cytidine deaminases from B. subtilis and E. coli: compensating effects of changing zinc coordination and quaternary structure.
TLDR
B. subtilis and E. coli enzymes are found to be similar in their activities, and also in their relative binding affinities for a series of structurally related inhibitors with binding Affinities that span a range of 6 orders of magnitude. Expand
Role of glutamate-104 in generating a transition state analogue inhibitor at the active site of cytidine deaminase.
TLDR
19F-NMR indicates, however, that the E104A mutant enzyme binds the inhibitor without modification, in a form that resembles the substrate in the ground state, consistent with a major role for Glu-104, not only in stabilizing the ES++ complex in the transition state, but also in destabilizing theES complex inThe ground state. Expand
FGF23 Modifies the Relationship Between Vitamin D and Cardiac Remodeling
TLDR
The findings suggest that consideration of both hormones is crucial to understanding the role of either in cardiac remodeling, and may have important therapeutic implications. Expand
Hypoadiponectinemia, Dyslipidemia, and Impaired Growth in Children with HIV-associated Facial Lipoatrophy
TLDR
The presence of facial lipoatrophy in a child with HIV infection is a marker for significant metabolic derangements including dyslipidemia and hypoadiponectinemia, and suggests the need for careful growth evaluation. Expand
Removal of gadolinium by peritoneal dialysis.
TLDR
For patients on chronic maintenance PD who receive gadolinium, this case suggests that a temporary intensive automated PD regimen, aimed at maximizing clearance of this contrast agent immediately after exposure, could be an effective alternative when institution of HD is problematic. Expand
Cloning and nucleotide sequence of the Escherichia coli cytidine deaminase (ccd) gene.
The structural gene that encodes cytidine deaminase (cdd) in Escherichia coli was cloned from Kohara phage lambda 365 (7F1), and its nucleotide sequence was determined. Plasmids harboring the geneExpand
Mutations affecting transition-state stabilization by residues coordinating zinc at the active site of cytidine deaminase.
TLDR
Affinities of the mutant cytidine deaminases for the transition-state analogue, 5-fluoropyrimidin-2-one ribonucleoside (3,4) hydrate, were found to decrease in rough proportion to kcat/Km over a range spanning several orders of magnitude, indicating the involvement of zinc coordination in the catalytic process rather than in substrate binding. Expand
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