Physical Performance and Frailty in Chronic Kidney Disease
- P. Reese, A. Cappola, M. Leonard
- MedicineAmerican Journal of Nephrology
- 1 October 2013
CKD severity was associated with poor physical performance and frailty in a graded fashion and future trials should determine if outcomes for CKD patients with frailty andpoor physical performance are improved by targeted interventions.
A cross-sectional study of vitamin D and insulin resistance in children
- A. Kelly, L. Brooks, Shayne Dougherty, D. Carlow, B. Zemel
- MedicineArchives of Disease in Childhood
- 1 February 2011
Low 25-OH-D, common in the paediatric population at risk for diabetes (older children, African–Americans, children with increasing BMI-Z) is associated with worse insulin resistance.
FGF23 Modifies the Relationship Between Vitamin D and Cardiac Remodeling
- B. Ky, J. Shults, M. Leonard
- Medicine, BiologyCirculation: Heart Failure
- 1 July 2013
The findings suggest that consideration of both hormones is crucial to understanding the role of either in cardiac remodeling, and may have important therapeutic implications.
Development and validation of a turbulent flow chromatography and tandem mass spectrometry method for the quantitation of methotrexate and its metabolites 7-hydroxy methotrexate and DAMPA in serum.
- Ryan C. Schofield, L. Ramanathan, D. Carlow
- Chemistry, MedicineJournal of chromatography. B, Analytical…
- 1 October 2015
Topical tacrolimus for the treatment of secondary lymphedema
- J. Gardenier, R. Kataru, B. Mehrara
- Medicine, BiologyNature Communications
- 10 February 2017
This intervention markedly decreases swelling, T-cell infiltration and tissue fibrosis while significantly increasing formation of lymphatic collaterals with minimal systemic absorption, and Animals treated with tacrolimus have markedly improved lymphatic function.
Cytidine deaminases from B. subtilis and E. coli: compensating effects of changing zinc coordination and quaternary structure.
- D. Carlow, C. Carter, N. Mejlhede, J. Neuhard, R. Wolfenden
- Biology, ChemistryBiochemistry
- 1 September 1999
B. subtilis and E. coli enzymes are found to be similar in their activities, and also in their relative binding affinities for a series of structurally related inhibitors with binding Affinities that span a range of 6 orders of magnitude.
Major contribution of a carboxymethyl group to transition-state stabilization by cytidine deaminase: mutation and rescue.
- D. Carlow, A. A. Smith, C. Yang, S. Short, R. Wolfenden
- Biology, ChemistryBiochemistry
- 4 April 1995
By its presence, the carboxymethyl group of Glu-104 appears to minimize the activation barrier for deamination, not only by stabilizing the altered substrate in the transition state but also by destabilizing the enzyme-substrate and enzyme-product complexes.
Role of glutamate-104 in generating a transition state analogue inhibitor at the active site of cytidine deaminase.
- D. Carlow, S. Short, R. Wolfenden
- Chemistry, BiologyBiochemistry
- 23 January 1996
19F-NMR indicates, however, that the E104A mutant enzyme binds the inhibitor without modification, in a form that resembles the substrate in the ground state, consistent with a major role for Glu-104, not only in stabilizing the ES++ complex in the transition state, but also in destabilizing theES complex inThe ground state.
Polyethylene Glycol Powder Solution Versus Senna for Bowel Preparation for Colonoscopy in Children
- N. Terry, Mei Lin Chen-Lim, P. Mamula
- MedicineJournal of Pediatric Gastroenterology and…
- 1 February 2013
PEG-P is an effective colonoscopy preparation whereas senna preparation was insufficient and both were well-tolerated and appear safe in a pediatric population.
Removal of gadolinium by peritoneal dialysis.
- M. Murashima, H. Drott, R. Bloom
- MedicineClinical Nephrology
- 1 May 2008
For patients on chronic maintenance PD who receive gadolinium, this case suggests that a temporary intensive automated PD regimen, aimed at maximizing clearance of this contrast agent immediately after exposure, could be an effective alternative when institution of HD is problematic.
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