• Publications
  • Influence
Three-Dimensional Architecture of Presynaptic Terminal Cytomatrix
TLDR
3D analysis reveals the morphological constraints exerted by the presynaptic molecular scaffold and links SVs are tightly interconnected in the axonal bouton, and this network is preferentially connected to the AZ.
Hair cell synaptic ribbons are essential for synchronous auditory signalling
TLDR
It is concluded that ribbon-dependent synchronous release of multiple vesicles at the hair cell afferent synapse is essential for normal hearing.
Molecular organization of the presynaptic active zone
TLDR
Five protein families whose members are highly enriched at active zones (Munc13s, RIMs, ELKS proteins, Piccolo and Bassoon, and the liprins-α), have been characterized and are instrumental for the diverse functions performed by the presynaptic active zone.
Molecular dissection of the photoreceptor ribbon synapse
TLDR
The RIBEYE homologue CtBP1 is found at ribbon and conventional synapses, suggesting a novel role for the CtBP/BARS family in the molecular assembly and function of central nervous system synapses.
Bassoon, a Novel Zinc-finger CAG/Glutamine-repeat Protein Selectively Localized at the Active Zone of Presynaptic Nerve Terminals
TLDR
It is shown that Bassoon, a novel protein of >400,000 M r, is a new component of the presynaptic cytoskeleton, and biochemical studies suggest a tight association with cytoskeletal structures.
BDNF and its pro-peptide are stored in presynaptic dense core vesicles in brain neurons
TLDR
Specific immunohistochemical localization of brain-derived neurotrophic factor in the central nervous system supports the alternative model of presynaptic localization and anterograde function.
...
...