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PARP1 protein, human

Known as: ADPRT 1, Poly(ADP Ribose) Polymerase, NAD(+) ADP-Ribosyltransferase 1 
Poly [ADP-ribose] polymerase 1 (1013aa, ~113 kDa) is encoded by the human PARP1 gene. This protein is involved in poly ADP-ribosylation and in the… 
National Institutes of Health

Related topics

Related topics

32 relations
AIF PathwayAZD2461BRCT DomainBase Excision Repair

Broader (2)

Poly (ADP-Ribose) Polymerase-1Poly(ADP-ribose) Polymerases

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2012
Review
2012
The diverse roles and clinical relevance of PARPs in DNA damage repair: current state of the art.
Review
2010
Review
2010
PARP-1 cleavage fragments: signatures of cell-death proteases in neurodegeneration
The normal function of poly (ADP-ribose) polymerase-1 (PARP-1) is the routine repair of DNA damage by adding poly (ADP ribose… 
Review
2008
Review
2008
The expanding field of poly(ADP-ribosyl)ation reactions. ‘Protein Modifications: Beyond the Usual Suspects' Review Series
Poly(ADP‐ribosyl)ation is a post‐translational modification of proteins that is mediated by poly(ADP‐ribose) polymerases (PARPs… 
Highly Cited
2001
Highly Cited
2001
Novel proteasome inhibitor PS-341 inhibits activation of nuclear factor-kappa B, cell survival, tumor growth, and angiogenesis in squamous cell carcinoma.
We have shown that activation of nuclear factor-kappa B (NF-kappa B) promotes cell survival and expression of cytokines such as… 
Review
2000
Review
2000
Poly(ADP-ribose) polymerase-1: what have we learned from the deficient mouse model?
Highly Cited
1999
Highly Cited
1999
PARP-2, A Novel Mammalian DNA Damage-dependent Poly(ADP-ribose) Polymerase*
Poly(ADP-ribosylation) is a post-translational modification of nuclear proteins in response to DNA damage that activates the base… 
Highly Cited
1998
Highly Cited
1998
XRCC1 Is Specifically Associated with Poly(ADP-Ribose) Polymerase and Negatively Regulates Its Activity following DNA Damage
ABSTRACT Poly(ADP-ribose) polymerase (PARP; EC 2.4.2.30 ) is a zinc-finger DNA-binding protein that detects and signals DNA… 
Highly Cited
1998
Highly Cited
1998
Importance of Poly(ADP-ribose) Polymerase and Its Cleavage in Apoptosis
We have studied the apoptotic response of poly(ADP-ribose) polymerase (PARP)−/− cells to different inducers and the consequences… 
Highly Cited
1997
Highly Cited
1997
Requirement of poly(ADP-ribose) polymerase in recovery from DNA damage in mice and in cells.
Poly(ADP-ribose) polymerase [PARP; NAD+ ADP-ribosyltransferase; NAD+: poly(adenosine-diphosphate-D-ribosyl)-acceptor ADP-D… 
Review
1995
Review
1995
Post-translational modification of poly(ADP-ribose) polymerase induced by DNA strand breaks.
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