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PARP-1 cleavage fragments: signatures of cell-death proteases in neurodegeneration
The normal function of poly (ADP-ribose) polymerase-1 (PARP-1) is the routine repair of DNA damage by adding poly (ADP ribose) polymers in response to a variety of cellular stresses. Recently, it hasExpand
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Role of the endothelium in inflammatory bowel diseases.
Inflammatory bowel diseases (IBD) are a complex group of diseases involving alterations in mucosal immunity and gastrointestinal physiology during both initiation and progressive phases of theExpand
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Differential cytokine responses in human and mouse lymphatic endothelial cells to cytokines in vitro.
BACKGROUND Inflammatory cytokines dysregulate microvascular function, yet how cytokines affect lymphatic endothelial cells (LEC) are unclear. METHODS AND RESULTS We examined effects of TNF-α, IL-1Expand
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Emerging roles of lymphatics in inflammatory bowel disease
The mobilization and recruitment of blood and lymphatic vasculatures are widely described in inflammatory bowel diseases (IBDs). Although angiogenesis contributes to intense gut inflammation, itExpand
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Discovery of transcriptional programs in cerebral ischemia by in silico promoter analysis
In stroke, gene transcription plays a central role in processes such as neuroinflammation and neuroregeneration. To predict new transcriptional regulatory mechanisms in cerebral ischemia, we appliedExpand
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Activation of Calpain, Cathepsin-b and Caspase-3 during Transient Focal Cerebral Ischemia in Rat Model
Calpains, cathepsins and caspases play crucial role in mediating cell death. In the present study we observed a cascade of events involving the three proteases during middle cerebral artery occlusionExpand
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Differential PARP Cleavage: An Indication of Heterogeneous Forms of Cell Death and Involvement of Multiple Proteases in the Infarct of Focal Cerebral Ischemia in Rat
Aim Poly (ADP-ribose) polymerase (PARP) is a nuclear repair enzyme whose role is widely depicted in various physiological and pathological processes. In the present study, we wanted to check theExpand
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Gliovascular and cytokine interactions modulate brain endothelial barrier in vitro
The glio-vascular unit (G-unit) plays a prominent role in maintaining homeostasis of the blood-brain barrier (BBB) and disturbances in cells forming this unit may seriously dysregulate BBB. TheExpand
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Proteolytic breakdown of cytoskeleton induces neurodegeneration during pathology of murine cerebral malaria
Fatal murine cerebral malaria is known to induce cellular degeneration by altering cellular morphology and integrity of cell. The morphology and integrity of the cell mainly depends on theExpand
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Multiple apoptogenic proteins are involved in the nuclear translocation of Apoptosis Inducing Factor during transient focal cerebral ischemia in rat
Apoptosis Inducing Factor is a mitochondrial protein which upon translocation to nucleus causes large scale DNA fragmentation. The stimulus for the cytosolic release and nuclear translocation forExpand
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