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PARN gene

Known as: DEADENYLATING NUCLEASE, DAN, deadenylation nuclease 
 
National Institutes of Health

Papers overview

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Highly Cited
2015
Highly Cited
2015
Idiopathic pulmonary fibrosis (IPF) is an age-related disease featuring progressive lung scarring. To elucidate the molecular… Expand
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Highly Cited
2006
Highly Cited
2006
Cytoplasmic polyadenylation is one mechanism that regulates translation in early animal development. In Xenopus oocytes… Expand
Highly Cited
2006
Highly Cited
2006
CUG-BP is the human homolog of the Xenopus EDEN-BP, which was shown previously to bind to mRNAs, such as c-mos, that exhibit… Expand
Highly Cited
2003
Highly Cited
2003
In Saccharomyces cerevisiae, a large complex, known as the Ccr4–Not complex, containing two nucleases, is responsible for mRNA… Expand
Highly Cited
2001
Highly Cited
2001
While decapping plays a major role in mRNA turnover in yeast, biochemical evidence for a similar activity in mammalian cells has… Expand
Review
2000
Review
2000
During the past two years, the role of the proteins HuR and hnRNP D in regulated mRNA degradation in humans has become clearer… Expand
Highly Cited
2000
Highly Cited
2000
Poly(A) tail removal is often the initial and rate‐limiting step in mRNA decay and is also responsible for translational… Expand
Review
1999
Review
1999
  • J. Richter
  • Microbiology and Molecular Biology Reviews
  • 1999
  • Corpus ID: 18622676
SUMMARY Maternal mRNA translation is regulated in large part by cytoplasmic polyadenylation. This process, which occurs in both… Expand
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Highly Cited
1998
Highly Cited
1998
Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs and is also used to… Expand
Highly Cited
1997
Highly Cited
1997
3′-Exonucleolytic removal of the poly(A) tail is the first and often rate-limiting step in the decay of many eucaryotic mRNAs. In… Expand