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Distribution of selenium in human blood plasma and serum.
A method has been developed which separates the three major selenium-containing proteins found in human blood serum and plasma: selenoprotein-P, glutathione peroxidase and albumin, and the Se content determined directly by ETAAS was determined.
Cadmium concentrations in human kidney in the UK: 1978-1993.
Almost 2700 samples of human renal cortex have been collected from throughout the UK over a 16 year period from 1978 to 1993, finding that Cd increased from low concentration in the young to a maximum of 23 micrograms g-1 in middle age followed by a decrease in old age.
Histopathology of early effects of oral cadmium in the rat kidney.
Early pathological changes in the rat kidney were seen around the 4-6 week period which coincided with the distinct rise in plasma Cd, and preliminary investigation suggests that most is present as Cd-thionein.
Nickel metabolism in humans investigated with an oral stable isotope.
Low between-subject variability of nickel absorption and excretion was observed and confounding factors such as contamination and dietary intake of nickel, which hampered earlier measurements in subjects dosed with naturally abundant nickel, were eliminated by using the tracer isotope 62Ni.
Nickel dermatitis: the reaction to oral nickel challenge
A double‐blind crossover oral challenge with placebo (lactose) or the equivalent of 400 μg elemental nickel (as nickel sulphate), was performed on 10 nickel‐sensitive volunteers with hand dermatitis.…
Arrhythmia prophylaxis after coronary artery surgery. A randomised controlled trial of intravenous magnesium chloride.
Environmental exposure to metals of newborns, infants and young children
Determination of nine inorganic elements in human autopsy tissue.
- T. Lyon, G. Fell, D. Halls, J. Clark, F. McKenna
- MedicineJournal of trace elements and electrolytes in…
- 1 June 1989
A survey of nine elements of accepted clinical relevance has been performed on tissue sets comprising of kidney, liver, heart and muscle taken at autopsy from healthy individuals killed as the result of an accident, largely consistent with those reported from studies in other parts of the world.
Assessment of status.
The investigation of general populations for micronutrient depletions largely relies upon clinical and epidemiological evaluation of responses to controlled trials of supplementation.
Age dependence of potentially toxic elements (Sb, Cd, Pb, Ag) in human liver tissue from paediatric subjects.
- T. Lyon, M. Patriarca, G. Howatson, P. Fleming, P. Blair, G. Fell
- MedicineJournal of environmental monitoring : JEM
- 26 November 2002
Investigation of the age dependence of the liver content of selected elements in paediatric populations, as an index of internal exposure, provides further direct evidence that these elements cross the human placental barrier.