Skip to search formSkip to main contentSkip to account menu

Ondansetron

Known as: 4H-Carbazol-4-one, 1,2,3,9-tetrahydro-9-methyl-3-((2-methyl-1H-imidazol-1-yl)methyl)-, Ondansetron [Chemical/Ingredient], Ondansetron, (+,-)-Isomer 
A carbazole derivative with antiemetic activity. As a selective serotonin receptor antagonist, ondansetron competitively blocks the action of… 
National Institutes of Health

Related topics

Related topics

38 relations
2 ML Ondansetron 2 MG/ML InjectionAlcoholic Intoxication, ChronicCYP1A2 protein, humanCytochrome P450 2D6, human

Narrower (5)

8-hydroxyondansetronGR38032FOndansetron HydrochlorideSN-307

Broader (8)

Anti-Anxiety AgentsAntiemeticsAntipruriticsAntipsychotic Agents

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2006
Highly Cited
2006
Determinants of drug brain uptake in a rat model of seizure-associated malformations of cortical development
2006
2006
Luminal hypotonicity increases duodenal mucosal permeability by a mechanism involving 5‐hydroxytryptamine
Aim:  To investigate whether 5‐hydroxytryptamine (5‐HT) participates in the mediation of the hypotonicity‐induced increase in… 
1999
1999
Indian red scorpion (Buthus tamulus) venom-induced augmentation of cardiac reflexes is mediated through the involvement of peripheral 5-HT3 and central 5-HT1A receptor subtypes.
Highly Cited
1998
Highly Cited
1998
Docetaxel (Taxotere) plus cisplatin: an active and well-tolerated combination in patients with advanced non-small cell lung cancer.
1996
1996
5-HT3 receptor antagonists do not modify cocaine place conditioning or the rise in extracellular dopamine in the nucleus accumbens of rats
Highly Cited
1994
Highly Cited
1994
Single oral dose ondansetron in the prevention of postoperative nausea and emesis
In two placebo‐controlled, double‐blind, multicentre studies, the efficacy and safety of single oral doses of ondansetron 4mg… 
Review
1993
Review
1993
Global experience with ondansetron and future potential.
Ondansetron was first synthesised in 1983 and it is estimated that over 4 million patient treatments have been given with… 
1993
1993
Inhibition of 5-hydroxytryptamine- and enterotoxin-induced fluid secretion by 5-HT receptor antagonists in the rat jejunum.
1993
1993
Characterization of [3H]meta-chlorophenylbiguanide binding to 5-HT3 receptors in N1E-115 neuroblastoma cells.
Review
1989
Review
1989
Ondansetron in the prophylaxis of acute cisplatin-induced nausea and vomiting.
Nausea and vomiting occur in all patients following high-dose cisplatin chemotherapy, unless an effective anti-emetic is… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)