Serotonergic receptor mechanisms underlying antidepressant-like action in the progesterone withdrawal model of hormonally induced depression in rats

@article{Li2013SerotonergicRM,
  title={Serotonergic receptor mechanisms underlying antidepressant-like action in the progesterone withdrawal model of hormonally induced depression in rats},
  author={Yan Li and Kasper F. Raaby and Connie S{\'a}nchez and Maria E. Gulinello},
  journal={Behavioural Brain Research},
  year={2013},
  volume={256},
  pages={520-528}
}

Differential interaction with the serotonin system by S-ketamine, vortioxetine, and fluoxetine in a genetic rat model of depression

TLDR
It is suggested that the acute and sustained antidepressant- like effects of S-ketamine depend on endogenous stimulation of 5-HT receptors and the acute therapeutic-like effects of vortioxetine on memory and depression-like behavior may be mediated by direct activity at 5- HT receptors.

Drugs with antidepressant properties affect tryptophan metabolites differently in rodent models with depression‐like behavior

TLDR
Sustained vortioxetine and fluoxetine administration decreased QUIN independent of species, while ketamine was ineffective and supported the hypothesis that modulating tryptophan metabolism may be part of the mechanism of action for some antidepressants.

Effects of vortioxetine on biomarkers associated with glutamatergic activity in an SSRI insensitive model of depression in female rats

Paeonol at Certain Doses Alleviates Aggressive and Anxiety-Like Behaviours in Two Premenstrual Dysphoric Disorder Rat Models

TLDR
Paeonol is a potential therapeutic compound for PMS/PMDD; it is a drug option that helps establish dosage guidance for treatment of this condition and demonstrates excellent effects in improving anxiety, particularly irritable emotional behaviour.

Vortioxetine in major depressive disorder: from mechanisms of action to clinical studies. An updated review

TLDR
Vortioxetine is the first antidepressant that has shown improvements both in depression and cognitive symptoms, due to the unique multimodal mechanism of action that combine the 5-HT reuptake inhibition with modulations of other key pre- and post-synaptic 5- HT receptors.

Vortioxetine, a novel antidepressant with multimodal activity: review of preclinical and clinical data.

Vortioxetine: a novel antidepressant for the treatment of major depressive disorder

TLDR
Vortioxetine’s unique psychopharmacological properties might contribute to an improved clinical outcome in MDD patient populations as described in published preclinical and clinical studies and product labels.
...

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