Serotonergic receptor mechanisms underlying antidepressant-like action in the progesterone withdrawal model of hormonally induced depression in rats

  title={Serotonergic receptor mechanisms underlying antidepressant-like action in the progesterone withdrawal model of hormonally induced depression in rats},
  author={Yan Li and Kasper F. Raaby and Connie S{\'a}nchez and Maria E. Gulinello},
  journal={Behavioural Brain Research},

Differential interaction with the serotonin system by S-ketamine, vortioxetine, and fluoxetine in a genetic rat model of depression

It is suggested that the acute and sustained antidepressant- like effects of S-ketamine depend on endogenous stimulation of 5-HT receptors and the acute therapeutic-like effects of vortioxetine on memory and depression-like behavior may be mediated by direct activity at 5- HT receptors.

Drugs with antidepressant properties affect tryptophan metabolites differently in rodent models with depression‐like behavior

Sustained vortioxetine and fluoxetine administration decreased QUIN independent of species, while ketamine was ineffective and supported the hypothesis that modulating tryptophan metabolism may be part of the mechanism of action for some antidepressants.

Effects of vortioxetine on biomarkers associated with glutamatergic activity in an SSRI insensitive model of depression in female rats

Paeonol at Certain Doses Alleviates Aggressive and Anxiety-Like Behaviours in Two Premenstrual Dysphoric Disorder Rat Models

Paeonol is a potential therapeutic compound for PMS/PMDD; it is a drug option that helps establish dosage guidance for treatment of this condition and demonstrates excellent effects in improving anxiety, particularly irritable emotional behaviour.

Vortioxetine in major depressive disorder: from mechanisms of action to clinical studies. An updated review

Vortioxetine is the first antidepressant that has shown improvements both in depression and cognitive symptoms, due to the unique multimodal mechanism of action that combine the 5-HT reuptake inhibition with modulations of other key pre- and post-synaptic 5- HT receptors.

Vortioxetine, a novel antidepressant with multimodal activity: review of preclinical and clinical data.

Vortioxetine: a novel antidepressant for the treatment of major depressive disorder

Vortioxetine’s unique psychopharmacological properties might contribute to an improved clinical outcome in MDD patient populations as described in published preclinical and clinical studies and product labels.



5-HT1A receptor function in major depressive disorder

Antidepressant-like effects of serotonin type-3 antagonist, ondansetron: an investigation in behaviour-based rodent models

It is observed that OND exhibits antidepressant-like effects, possibly mediated through postsynaptic 5-HT3 receptors, in the forced swim and tail suspension tests.

Anti-depressant-like activity of a novel serotonin type-3 (5-HT3) receptor antagonist in rodent models of depression.

Reversation of parthenolide induced depression in mice and reserpine induced hypothermia in rat models indicate the serotonergic influence of QCM-13 for anti-depressant potential.

Pharmacological Blockade of 5-HT7 Receptors as a Putative Fast Acting Antidepressant Strategy

Findings indicate that the 5-HT7 receptor antagonists may represent a new class of antidepressants with faster therapeutic action than the commonly prescribed antidepressant fluoxetine.

Effects of combined administration of 5-HT1A and/or 5-HT1B receptor antagonists and paroxetine or fluoxetine in the forced swimming test in rats.

The obtained results seem to indicate that blockade of 5- HT1B receptors, but not 5-HT1A ones, can facilitate the antidepressant-like effect of paroxetine in the forced swimming test in rats.