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Oncogene YES-1

Known as: YES1, YES1 Gene 
The gene product of oncogene YES-1 is associated with tyrosine kinase activity and its amino acid sequence shows high similarity with that of SRC… 
National Institutes of Health

Related topics

Related topics

7 relations
18p11.31-p11.21Homo sapiensNeoplastic Cell TransformationProtein phosphorylation

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2019
Highly Cited
2019
Circ_Lrp6, a Circular RNA Enriched in Vascular Smooth Muscle Cells, Acts as a Sponge Regulating miRNA-145 Function
Rationale: microRNAs (miRNAs) modulate gene expression by repressing translation of targeted genes. Previous work has established… 
2019
2019
YES1 Drives Lung Cancer Growth and Progression and Predicts Sensitivity to Dasatinib.
RATIONALE the characterization of new genetic alterations is essential to assign effective personalized therapies in non-small… 
2017
2017
Yes1 signaling mediates the resistance to Trastuzumab/Lap atinib in breast cancer
Background Overexpression of human epidermal growth factor receptor 2 (HER2) is observed in approximately 15–23% of breast… 
Highly Cited
2016
Highly Cited
2016
Long noncoding RNA H19 competitively binds miR‐17‐5p to regulate YES1 expression in thyroid cancer
The long noncoding RNA H19 is overexpressed in many cancers and acts as an oncogene. Here, we investigated the role of H19 in… 
2015
2015
MiR‐17–5p Up‐Regulates YES1 to Modulate the Cell Cycle Progression and Apoptosis in Ovarian Cancer Cell Lines
MicroRNAs (miRNAs) are small, non‐coding RNAs that participate in the regulation of gene expression. Although many studies have… 
Highly Cited
2014
Highly Cited
2014
The Inhibition of Src Family Kinase Suppresses Pancreatic Cancer Cell Proliferation, Migration, and Invasion
Objectives Src is considered a rising therapeutic target for the treatment of solid tumors, and Src family kinases (SFKs… 
2010
2010
Identification of the YES1 Kinase as a Therapeutic Target in Basal-Like Breast Cancers.
Normal cellular behavior can be described as a complex, regulated network of interaction between genes and proteins. Targeted… 
Highly Cited
2008
Highly Cited
2008
Binding of the proline-rich segment of myelin basic protein to SH3 domains: spectroscopic, microarray, and modeling studies of ligand conformation and effects of posttranslational modifications.
Myelin basic protein (MBP) is a multifunctional protein involved in maintaining the stability and integrity of the myelin sheath… 
2002
2002
Novel targets for the 18p11.3 amplification frequently observed in esophageal squamous cell carcinomas.
Amplification of DNA in certain chromosomal regions, with consequent over-expression of specific genes within these amplicons… 
Highly Cited
2001
Highly Cited
2001
Pharmacogenomic dissection of resistance to thymidylate synthase inhibitors.
Chemoresistance is a major obstacle for successful cancer treatment. Gene amplification and altered expression are the main… 
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