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Causal Relationship between the Loss of RUNX3 Expression and Gastric Cancer
Runx3/Pebp2alphaC null mouse gastric mucosa exhibits hyperplasias due to stimulated proliferation and suppressed apoptosis in epithelial cells, and the cells are resistant to growth-inhibitory andExpand
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Exploration of tumor-suppressive microRNAs silenced by DNA hypermethylation in oral cancer.
In the last few years, microRNAs (miRNA) have started a revolution in molecular biology and emerged as key players in the carcinogenesis. They have been identified in various tumor types, showingExpand
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HSF4, a new member of the human heat shock factor family which lacks properties of a transcriptional activator.
Heat shock transcription factors (HSFs) mediate the inducible transcriptional response of genes that encode heat shock proteins and molecular chaperones. In vertebrates, three related HSF genes (HSF1Expand
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Mutations in EFHC1 cause juvenile myoclonic epilepsy
Juvenile myoclonic epilepsy (JME) is the most frequent cause of hereditary grand mal seizures. We previously mapped and narrowed a region associated with JME on chromosome 6p12–p11 (EJM1). Here, weExpand
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miR-124 and miR-203 are epigenetically silenced tumor-suppressive microRNAs in hepatocellular carcinoma.
MicroRNAs (miRNAs) are a class of small non-coding RNAs that, in general, negatively regulate gene expression. They have been identified in various tumor types, showing that different sets of miRNAsExpand
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Variation in TP63 is associated with lung adenocarcinoma susceptibility in Japanese and Korean populations
Lung cancer is the most common cause of death from cancer worldwide, and its incidence is increasing in East Asian and Western countries. To identify genetic factors that modify the risk of lungExpand
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Human Fas ligand: gene structure, chromosomal location and species specificity.
Fas ligand (FasL) is a 40 kDa type II membrane protein belonging to the tumor necrosis factor family, which induces apoptosis by binding to its receptor, Fas. In this report, we isolated theExpand
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PH Domain-Only Protein PHLDA3 Is a p53-Regulated Repressor of Akt
p53 And Akt are critical players regulating tumorigenesis with opposite effects: whereas p53 transactivates target genes to exert its function as a tumor suppressor, Akt phosphorylates its substratesExpand
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Genome-wide association study identifies five new susceptibility loci for prostate cancer in the Japanese population
Prostate cancer is one of the most common malignancies in males throughout the world, and its incidence is increasing in Asian countries. We carried out a genome-wide association study andExpand
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PIK3CA mutation is an oncogenic aberration at advanced stages of oral squamous cell carcinoma
Phosphatidylinositol 3‐kinases (PI3K) are a group of heterodimeric lipid kinases that regulate many cellular processes. Gene amplification and somatic mutations mainly within the helical (exon 9) andExpand
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