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Reconstitution of IKATP: An Inward Rectifier Subunit Plus the Sulfonylurea Receptor
Gene mapping data indicate that these pancreatic β cell potassium channels are a complex composed of at least two subunits-BIR, a member of the inward rectifier potassium channel family, and SUR, a members of the ATP-binding cassette superfamily.
Causal Relationship between the Loss of RUNX3 Expression and Gastric Cancer
Exploration of tumor-suppressive microRNAs silenced by DNA hypermethylation in oral cancer.
Examination of expression profiles of 148 miRNAs in a panel of 18 oral squamous cell carcinoma cell lines and the immortalized oral keratinocyte line RT7 showed that miR-137 andmiR-193a are tumor suppressor miRNAAs epigenetically silenced during oral carcinogenesis.
Structure and chromosomal localization of the human stromal cell-derived factor 1 (SDF1) gene.
Stromal cell-derived factors 1 alpha and 1 beta are small cytokines belonging to the intercrine CXC subfamily and originally isolated from a murine bone-marrow stroma cell line by the signal sequence trap method, and strong evolutionary conservation and unique chromosomal localization of the SDF1 gene suggest that they may have important functions distinct from those of other members of the interCrine family.
Structure and Expression of the Ah Receptor Repressor Gene*
Both transient transfection analysis and gel mobility shift assay revealed that the AhRR gene is up-regulated by a p65/p50 heterodimer that binds to the NF-κB site when the cells has been exposed to 12-O-tetradecanoylphorbol-13-acetate, and this inducible expression was further enhanced by cotreatment of 3-methylcholanthrene.
miR-124 and miR-203 are epigenetically silenced tumor-suppressive microRNAs in hepatocellular carcinoma.
The results suggest thatmiR-124 and miR-203 are novel tumor-suppressive miRNAs for HCC epigenetically silenced and activating multiple targets during hepatocarcinogenesis.
Variation in TP63 is associated with lung adenocarcinoma susceptibility in Japanese and Korean populations
The results suggest that genetic variation in TP63 may influence susceptibility to lung adenocarcinoma in East Asian populations, and a SNP in intron 1 of TP63 showed the most significant association.
Mutations in EFHC1 cause juvenile myoclonic epilepsy
A new gene is described in this region, EFHC1, which encodes a protein with an EF-hand motif that is associated with juvenile myoclonic epilepsy and which increased R-type Ca2+ currents that were reversed by the mutations associated with JME.
PH Domain-Only Protein PHLDA3 Is a p53-Regulated Repressor of Akt
Human Fas ligand: gene structure, chromosomal location and species specificity.
- T. Takahashi, M. Tanaka, J. Inazawa, T. Abe, T. Suda, S. Nagata
- BiologyInternational immunology
- 1 October 1994
A comparison of human and mouse FasL chromosomal genes indicated that a approximately 300 bp sequence upstream of the ATG initiation codon is highly conserved between them, indicating that FasL fully cross-reacts between human andmouse.