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OTX2 gene

Known as: orthodenticle homeobox 2, Orthodenticle Homeobox 2 Gene, OTX2 
This gene is involved in both embryonic development and transcriptional regulation.
National Institutes of Health

Related topics

Related topics

10 relations
Cell Differentiation processEmbryonic DevelopmentHomo sapiensNeurogenesis

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2014
2014
Onset of rosette formation during spontaneous neural differentiation of hESC and hiPSC colonies.
2014
2014
sRNA‐seq Analysis of Human Embryonic Stem Cells and Definitive Endoderm Reveals Differentially Expressed MicroRNAs and Novel IsomiRs with Distinct Targets
MicroRNAs (miRNAs) are noncoding, regulatory RNAs expressed dynamically during differentiation of human embryonic stem cells… 
Review
2012
Review
2012
A novel OTX2 mutation in a patient with combined pituitary hormone deficiency, pituitary malformation, and an underdeveloped left optic nerve.
Orthodenticle homolog 2 (OTX2) is a homeobox family transcription factor required for brain and eye formation. Various genetic… 
2012
2012
MiR-206 Regulates Neural Cells Proliferation and Apoptosis via Otx2
MiR-206 was involved in a series of cellular activities, such as the growth and development of skeletal muscle and the… 
Highly Cited
2008
Highly Cited
2008
Differentially expressed genes are marked by histone 3 lysine 9 trimethylation in human cancer cells
Histone H3 lysine 9 trimethylation (H3K9Me3) has been associated with transcriptional repression, but recent findings implicate… 
Highly Cited
2006
Highly Cited
2006
Expression of the Otx2 homeobox gene in the developing mammalian brain: embryonic and adult expression in the pineal gland
Otx2 is a vertebrate homeobox gene, which has been found to be essential for the development of rostral brain regions and appears… 
2005
2005
Alternative usage of Otx2 promoters during mouse development
Our previous structural analysis of mouse Otx2 transcripts has revealed the existence of three different promoters and suggested… 
Highly Cited
2004
Highly Cited
2004
Otx2 homeobox gene induces photoreceptor-specific phenotypes in cells derived from adult iris and ciliary tissue.
PURPOSE It remains unclear which gene induction effectively generates photoreceptor-specific phenotypes from nonretinal tissues… 
1998
1998
A potential role for the OTX2 homeoprotein in creating early 'highways' for axon extension in the rostral brain.
Brain pattern formation starts with a subdivision of the neuroepithelium through site-specific expression of regulatory genes and… 
Highly Cited
1996
Highly Cited
1996
Otx1 function overlaps with Otx2 in development of mouse forebrain and midbrain
Background: We previously reported that the homozygous mutation of Otx2 gene, a mouse cognate of the Drosophila head gap gene… 
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