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Mouse Otx2 functions in the formation and patterning of rostral head.
The homo- and heterozygous mutant phenotypes suggest Otx2 functions as a gap-like gene in the rostral head where Hox code is not present, suggesting its evolutionary significance for the innovation of the neurocranium and the jaw.
Emx1 and Emx2 functions in development of dorsal telencephalon.
Phenotypes of newborn brains also suggest that these genes function in neurogenesis corresponding to their later expressions, and Emx2 most likely delineates the palliochoroidal boundary in the absence of Emx1 expression during early dorsal forebrain patterning.
A novel transgenic technique that allows specific marking of the neural crest cell lineage in mice.
It is believed that P0-Cre transgenic mice will facilitate many interesting experiments, including lineage analysis, purification, and genetic manipulation of the mammalian neural crest cells.
Defects of urogenital development in mice lacking Emx2.
The results suggest that, in metanephrogenesis, Emx2 is essential for the ureteric bud functions subsequent to Pax-2 induction in the meetanephric mesenchyme.
Evolution of the vertebral formulae in mammals: a perspective on developmental constraints.
The changes in the vertebral formulae in eutherian mammals seem to be lineage-specific, such that most species in Carnivora have 20 instead of 19 thoracolumbar vertebrae, which concluded that developmental constraints played an important role in the evolution of mammalian vertebralformulae.
Comparative transcriptome analysis reveals vertebrate phylotypic period during organogenesis
It is shown that the pharyngula stage is most conserved, whereas earlier and later stages are rather divergent, and this results allow us to predict approximate developmental timetables between different species, and indicate that phARYngula embryos have the most Conserved gene expression profiles, which may be the source of the basic body plan of vertebrates.
Pax-6 is involved in the specification of hindbrain motor neuron subtype.
Results strongly suggest that Pax-6 is involved in the specification of subtypes of hindbrain motor neurons, presumably through the regulation of Islet-2 and Wnt-7b expression.
The draft genomes of soft–shell turtle and green sea turtle yield insights into the development and evolution of the turtle–specific body plan
The results suggest that turtle evolution was accompanied by an unexpectedly conservative vertebrate phylotypic period, followed by turtle-specific repatterning of development to yield the novel structure of the shell.
Identification and expression of the lamprey Pax6 gene: evolutionary origin of the segmented brain of vertebrates.
- Y. Murakami, M. Ogasawara, F. Sugahara, S. Hirano, N. Satoh, S. Kuratani
- 15 September 2001
Most of the segmented domains of the vertebrate brain were already established in the ancestor common to all vertebrates, suggesting major evolutionary changes in the vertebrates may have involved local restriction of cell lineages, leading to the establishment of neuromeres.
Spatiotemporal expression patterns of chicken ovalbumin upstream promoter-transcription factors in the developing mouse central nervous system: evidence for a role in segmental patterning of the…
- Y. Qiu, A. Cooney, S. Kuratani, F. Demayo, S. Tsai, M. Tsai
- BiologyProceedings of the National Academy of Sciences…
- 10 May 1994
The results suggest that murine COUP-TFs may play important roles in the development and differentiation of the CNS, including the specification of diencephalic neuromeres.