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OROTATE PHOSPHORIBOSYLTRANSFERASE

Known as: Phosphohydrolase, Orotidine-5'-Monophosphate, OMPase, orotidine 5' phosphoate pyrophosphorylase 
The enzyme catalyzing the formation of orotidine-5'-phosphoric acid (orotidylic acid) from orotic acid and 5-phosphoribosyl-1-pyrophosphate in the… 
National Institutes of Health

Related topics

Related topics

13 relations

Narrower (2)

Hereditary orotic aciduria, type 1uridine 5'-monophosphate synthase
In BloodOrotate phosphoribosyltransferase:CCnc:Pt:Ser:QnProcess of secretionUMPS gene

Broader (1)

pentosyltransferase

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2005
Highly Cited
2005
A novel enzyme complex of orotate phosphoribosyltransferase and orotidine 5'-monophosphate decarboxylase in human malaria parasite Plasmodium falciparum: physical association, kinetics, and…
Human malaria parasite, Plasmodium falciparum, can only synthesize pyrimidine nucleotides using the de novo pathway, whereas… 
Highly Cited
1994
Highly Cited
1994
Crystal structure of orotate phosphoribosyltransferase.
Phosphoribosyltransferases (PRTases) are enzymes involved in the synthesis of purine, pyrimidine, and pyridine nucleotides. They… 
1990
1990
Kinetic mechanism of orotate phosphoribosyltransferase from Salmonella typhimurium.
The chemical mechanism of the phosphoribosyltransferases (PRTases), although largely unknown, may proceed either via a concerted… 
1983
1983
Orotidylate-metabolizing enzymes of the human malarial parasite, Plasmodium falciparum, differ from host cell enzymes.
Highly Cited
1982
Highly Cited
1982
UMP synthesis in the kinetoplastida.
Highly Cited
1982
Highly Cited
1982
Involvement of the glycosome of trypanosoma brucei in carbon dioxide fixation
Highly Cited
1980
Highly Cited
1980
Enzymology of human colon tumors.
1980
1980
Dynamics of modulation of biochemical programs in cancer cells.
Highly Cited
1979
Highly Cited
1979
Studies of the kinetic mechanism of orotate phosphoribosyltransferase from yeast.
Kinetic analysis of the reaction catalyzed by a homogeneous preparation of orotate phosphoribosyltransferase from yeast has… 
Highly Cited
1975
Highly Cited
1975
Studies on a pyrimidine phosphoribosyltransferase from murine leukemia P1534J. Partial purification, substrate specificity, and evidence for its existence as a bifunctional complex with orotidine 5…
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