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The Genome of the African Trypanosome Trypanosoma brucei
Comparisons of the cytoskeleton and endocytic trafficking systems of Trypanosoma brucei with those of humans and other eukaryotic organisms reveal major differences. Expand
Retooling Leishmania metabolism: from sand fly gut to human macrophage
The results indicate that the differentiating parasite shifts from glucose to fatty acids and amino acids as its main energy source, compensating for lack of exogenous sugars. Expand
Compartmentation of carbohydrate metabolism in trypanosomes.
  • F. Opperdoes
  • Biology, Medicine
  • Annual review of microbiology
  • 1987
Localization of nine glycolytic enzymes in a microbody‐like organelle in Trypanosoma brucei: The glycosome
The glycolytic pathway is modified in two respects: glucose is converted into pyruvate rather than lactate and the NADH produced in glycol- ysis is reoxidized indirectly by O2 via the coupled action of NAD’-linked glycerol-3-phosphate dehydro- genase and glycerolytic oxidase. Expand
Experimental and in Silico Analyses of Glycolytic Flux Control in Bloodstream Form Trypanosoma brucei*
Data obtained support the conclusion from the in silico analysis that HXK, PFK, and PYK are in excess, albeit less than predicted, and suggest the existence of novel regulatory mechanisms operating in trypanosome glycolysis. Expand
Characterization of the ysa Pathogenicity Locus in the Chromosome of Yersinia enterocolitica and Phylogeny Analysis of Type III Secretion Systems
This study describes the ysa locus from A127/90, another strain of serotype O:8, and extends the sequence to several new genes encoding Ysp proteins which are the substrates of this secretion system, and a putative chaperone SycB. Expand
The Trypanosoma cruzi Proteome
A whole-organism, proteomic analysis of the four life-cycle stages of Trypanosoma cruzi found that the four parasite stages appear to use distinct energy sources, including histidine for stages present in the insect vectors and fatty acids by intracellular amastigotes. Expand
Metabolism of Leishmania: proven and predicted.
The complete analysis of the genomes of three major trypanosomatid parasites has facilitated comparison of the metabolic capabilities of each, as predicted from gene sequences, and gene predictions with the results from experimental studies are related. Expand
Plant-like traits associated with metabolism of Trypanosoma parasites
Molecular evidence is presented that trypanosomatids possessed a plastid at some point in their evolutionary history and that kinetoplastids and euglenoids acquired plastids by endosymbiosis before their divergence and that the former lineage subsequently lost the organelle but retained numerous genes. Expand
Purification, morphometric analysis, and characterization of the glycosomes (microbodies) of the protozoan hemoflagellate Trypanosoma brucei
Trypanosoma brucei glycosomes (microbodies containing nine enzymes involved in glycolysis) have been purified to near homogeneity from bloodstream-form trypomastigotes for the purpose of morphologicExpand