• Publications
  • Influence
A microfluidic model for single-cell capillary obstruction by Plasmodium falciparum-infected erythrocytes
Severe malaria by Plasmodium falciparum is a potentially fatal disease, frequently unresponsive to even the most aggressive treatments. Host organ failure is associated with acquired rigidity ofExpand
  • 381
  • 13
  • PDF
Variations in frequencies of drug resistance in Plasmodium falciparum.
Continual exposure of malarial parasite populations to different drugs may have selected not only for resistance to individual drugs but also for genetic traits that favor initiation of resistance toExpand
  • 260
  • 11
  • PDF
Yeast dihydroorotate dehydrogenase as a new selectable marker for Plasmodium falciparum transfection.
Genetic manipulation of Plasmodium falciparum in culture through transfection has provided numerous insights into the molecular and cell biology of this parasite. The procedure is rather cumbersome,Expand
  • 72
  • 11
Antimalarial Drug Resistance: Literature Review and Activities and Findings of the ICEMR Network
Antimalarial drugs are key tools for the control and elimination of malaria. Recent decreases in the global malaria burden are likely due, in part, to the deployment of artemisinin-based combinationExpand
  • 159
  • 9
  • PDF
Chemical genetics of Plasmodium falciparum
Malaria caused by Plasmodium falciparum is a disease that is responsible for 880,000 deaths per year worldwide. Vaccine development has proved difficult and resistance has emerged for mostExpand
  • 454
  • 8
  • PDF
Malarial Dihydroorotate Dehydrogenase
The malarial parasite relies onde novo pyrimidine biosynthesis to maintain its pyrimidine pools, and unlike the human host cell it is unable to scavenge preformed pyrimidines. DihydroorotateExpand
  • 91
  • 8
Plasmodium dihydroorotate dehydrogenase: a promising target for novel anti-malarial chemotherapy.
Malaria remains a globally prevalent infectious disease that leads to significant morbidity and mortality. While there are a number of drugs approved for its treatment, drug resistance hasExpand
  • 137
  • 8
High-throughput Screening for Potent and Selective Inhibitors of Plasmodium falciparum Dihydroorotate Dehydrogenase*
Plasmodium falciparum is the causative agent of the most serious and fatal malarial infections, and it has developed resistance to commonly employed chemotherapeutics. The de novo pyrimidineExpand
  • 163
  • 7
  • PDF
Structural Plasticity of Malaria Dihydroorotate Dehydrogenase Allows Selective Binding of Diverse Chemical Scaffolds*
Malaria remains a major global health burden and current drug therapies are compromised by resistance. Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH) was validated as a new drug targetExpand
  • 97
  • 7
A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria
The antimalarial drug DSM265 displays activity against blood and liver stages of Plasmodium falciparum and has a long predicted half-life in humans. Long-acting new treatment for drug-resistantExpand
  • 196
  • 6
  • PDF