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ORMDL3 gene

Known as: ORM1-LIKE PROTEIN 3, ORMDL sphingolipid biosynthesis regulator 3, ORMDL3 
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2020
2020
Decreased sphingolipid synthesis in children with 17q21 asthma-risk genotypes.
Risk for childhood asthma is conferred by alleles within the 17q21 locus affecting ORMDL sphingolipid biosynthesis regulator 3… 
2020
2020
Long noncoding RNA SOX21‐AS1 regulates the progression of triple‐negative breast cancer through regulation of miR‐520a‐5p/ORMDL3 axis
Recently, long noncoding RNAs (lncRNAs) have been reported as a new kind of controllers about cancer processes in biology. In… 
Review
2018
Review
2018
Understanding the Unfolded Protein Response in the Pathogenesis of Asthma
Asthma is a heterogeneous, chronic inflammatory disease of the airways. It is a complex disease with different clinical… 
2017
2017
Prenatal phthalate exposure associates with low regulatory T‐cell numbers and atopic dermatitis in early childhood: Results from the LINA mother‐child study
2017
2017
Cutting Edge: Targeting Epithelial ORMDL3 Increases, Rather than Reduces, Airway Responsiveness and Is Associated with Increased Sphingosine-1-Phosphate
In this study, we used cre-lox techniques to generate mice selectively deficient in ORMDL3 in airway epithelium (Ormdl3Δ2-3/Δ2-3… 
Review
2016
Review
2016
The role of ORMDL proteins, guardians of cellular sphingolipids, in asthma
A family of widely expressed ORM‐like (ORMDL) proteins has been recently linked to asthma in genomewide association studies in… 
Highly Cited
2015
Highly Cited
2015
ORMDL/serine palmitoyltransferase stoichiometry determines effects of ORMDL3 expression on sphingolipid biosynthesis
The ORM1 (Saccharomyces cerevisiae)-like proteins (ORMDLs) and their yeast orthologs, the Orms, are negative homeostatic… 
Highly Cited
2013
Highly Cited
2013
Examination of the relationship between variation at 17q21 and childhood wheeze phenotypes.
2012
2012
GSDMB/ORMDL3 variants contribute to asthma susceptibility and eosinophil-mediated bronchial hyperresponsiveness.
2012
2012
17q12-21 variants are associated with asthma and interact with active smoking in an adult population from the United Kingdom.
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