All-Trans Retinoic Acid Modulates ORMDL3 Expression via Transcriptional Regulation

Abstract

All-trans retinoic acid (ATRA) is an active metabolite of Vitamin A, it shows protective effects on asthma, including maintains airway epithelial integrity, inhibits asthma effector cells differentiation, modulates immune response, et al. However, the promoting effect of ATRA on Th2 response has restricted the clinical application of ATRA in asthma… (More)
DOI: 10.1371/journal.pone.0077304

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