Deep Resequencing of Ulcerative Colitis-Associated Genes Identifies Novel Variants in Candidate Genes in the Korean Population.

  title={Deep Resequencing of Ulcerative Colitis-Associated Genes Identifies Novel Variants in Candidate Genes in the Korean Population.},
  author={Chang Mo Moon and Seung Won Kim and Jae Bum Ahn and Hyun Woo Ma and Xiumei Che and Tae Il Kim and Won Ho Kim and Jae Hee Cheon},
  journal={Inflammatory bowel diseases},
  volume={24 8},
Background Genome-wide association studies and meta-analyses have revealed the genetic background of ulcerative colitis (UC) by identifying common variants. However, these variants do not fully explain the disease variance in UC. To identify novel variants, we performed deep resequencing of UC-associated genes in Korean UC patients and subsequently investigated the functional roles of identified susceptibility genes. Methods We performed targeted deep resequencing of 108 genes in 24 Korean UC… 
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