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Guggulsterone inhibits angiogenesis by blocking STAT3 and VEGF expression in colon cancer cells.
It is suggested that guggulsterone not only induces apoptosis, but also inhibits angiogenesis and metastasis in colon cancer cells by blocking STAT3 and VEGF expression, suggesting its therapeutic potential in the treatment of colorectal cancer.
Bifidobacterium lactis inhibits NF‐&kgr;B in intestinal epithelial cells and prevents acute colitis and colitis‐associated colon cancer in mice
The data suggest that B. lactis could be a potential preventive agent for CAC as well as a therapeutic agent for inflammatory bowel disease.
Genetic polymorphisms of IL-23R and IL-17A and novel insights into their associations with inflammatory bowel disease
Insight is provided into the genetic and epigenetic interactions in the IL-23R/IL-17 axis that are associated with elevated expression of IL-17 and IBD pathogenesis and a significant inverse correlation between methylation extent of IVS1+17 and IL- 17A mRNA level.
Associations Between Genetic Variants in the IRGM Gene and Inflammatory Bowel Diseases in the Korean Population
This is the first study to identify SNP rs10065172 and rs72553867 in IRGM as principal CD susceptibility loci in an Asian population, and there was no significant association between the four SNPs and UC susceptibility.
Interleukin-33 regulates intestinal inflammation by modulating macrophages in inflammatory bowel disease
It is found that patients with IBD show decreased serum levels of IL-33 compared with healthy individuals and that IL- 33 can attenuate colitis and aid tissue repair in mice and the mechanism by whichIL-33 exerts these effects appears to involve the stimulation of differentiation of goblet cells and M2 macrophages.
A new histone deacetylase inhibitor improves liverfibrosis in BDL rats through suppression of hepatic stellate cells
A HDAC inhibitor is developed, N‐hydroxy‐7‐(2‐naphthylthio)heptanomide (HNHA) is investigated, and the anti‐fibrotic activity of HNHA is investigated in vitro and in vivo.
Latent progenitor cells as potential regulators for tympanic membrane regeneration
The study suggests that latent TM stem cells could be potential regulators of regeneration, which provides a new insight into this clinically important process and a potential target for new therapies for chronic otitis media and other eardrum injuries.