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ORC6L protein, human

Known as: origin recognition complex, subunit 6-like (yeast) protein, human, origin recognition complex, subunit 6, human, Origin Recognition Complex Subunit 6 
Origin recognition complex subunit 6 (252 aa, ~28 kDa) is encoded by the human ORC6 gene. This protein is involved in the positive regulation of DNA… 
National Institutes of Health

Related topics

Related topics

12 relations
Cell CycleCell Cycle ControlCell Viability ProcessDNA-Binding Proteins

Broader (2)

Origin Recognition Complex, Subunit 6origin recognition complex

Papers overview

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2013
2013
A Meier-Gorlin syndrome mutation in a conserved C-terminal helix of Orc6 impedes origin recognition complex formation
In eukaryotes, DNA replication requires the origin recognition complex (ORC), a six-subunit assembly that promotes replisome… 
Highly Cited
2011
Highly Cited
2011
CDK prevents Mcm2-7 helicase loading by inhibiting Cdt1 interaction with Orc6.
In Saccharomyces cerevisiae cells, B-type cyclin-dependent kinases (CDKs) target two origin recognition complex (ORC) subunits… 
Highly Cited
2009
Highly Cited
2009
Trypanosome Prereplication Machinery Contains a Single Functional Orc1/Cdc6 Protein, Which Is Typical of Archaea
ABSTRACT In unicellular eukaryotes, such as Saccharomyces cerevisiae, and in multicellular organisms, the replication origin is… 
Highly Cited
2007
Highly Cited
2007
Orc6 is required for dynamic recruitment of Cdt1 during repeated Mcm2-7 loading.
The origin recognition complex (ORC) nucleates DNA replication initiation in eukaryotic cells. This six-protein complex binds… 
Highly Cited
2004
Highly Cited
2004
Interaction of the S-phase cyclin Clb5 with an "RXL" docking sequence in the initiator protein Orc6 provides an origin-localized replication control switch.
Cyclin-dependent kinases are critical regulators of eukaryotic DNA replication. We show that the S-phase cyclin Clb5 binds stably… 
Highly Cited
2003
Highly Cited
2003
A cytokinetic function of Drosophila ORC6 protein resides in a domain distinct from its replication activity
Coordination between separate pathways may be facilitated by the requirements for common protein factors, a finding congruent… 
Highly Cited
2002
Highly Cited
2002
Orc6 Involved in DNA Replication, Chromosome Segregation, and Cytokinesis
Origin recognition complex (ORC) proteins serve as a landing pad for the assembly of a multiprotein prereplicative complex, which… 
Highly Cited
2001
Highly Cited
2001
Assembly of the Human Origin Recognition Complex*
The six-subunit origin recognition complex (ORC) was originally identified in the yeastSaccharomyces cerevisiae. Yeast ORC binds… 
Highly Cited
2001
Highly Cited
2001
Functional analysis of mutant and wild-type Drosophila origin recognition complex
The origin recognition complex (ORC) is the DNA replication initiator protein in eukaryotes. We have reconstituted a functional… 
Highly Cited
1996
Highly Cited
1996
Establishing genetic interactions by a synthetic dosage lethality phenotype.
We have devised a genetic screen, termed synthetic dosage lethality, in which a cloned "reference" gene is inducibly… 
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