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ORC3 gene

Known as: LATHEO, DROSOPHILA, HOMOLOG OF, origin recognition complex subunit 3, Origin Recognition Complex, Subunit 3-Like (Yeast) Gene 
This gene plays a role in DNA binding and the initiation of DNA replication. It is also involved in transcriptional silencing.
National Institutes of Health

Related topics

Related topics

6 relations
Cell Viability ProcessDNA ReplicationORC3 protein, humanReplication Initiation

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ORC3L wt Allele

Papers overview

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Highly Cited
2005
Highly Cited
2005
Single and Combined Deletions of the NTAL/LAB and LAT Adaptors Minimally Affect B-Cell Development and Function
ABSTRACT NTAL (non-T-cell activation linker, also called LAB) and LAT (linker for activation of T cells) are evolutionarily… 
Highly Cited
2004
Highly Cited
2004
Human Immunodeficiency Virus Type 1 Nef Associates with Lipid Rafts To Downmodulate Cell Surface CD4 and Class I Major Histocompatibility Complex Expression and To Increase Viral Infectivity
ABSTRACT Lipid rafts are membrane microdomains that are functionally distinct from other membrane regions. We have shown that 10… 
Highly Cited
2003
Highly Cited
2003
LAT links the pre-BCR to calcium signaling.
Review
2001
Review
2001
Mechanisms of signaling by the hematopoietic-specific adaptor proteins, SLP-76 and LAT and their B cell counterpart, BLNK/SLP-65.
Highly Cited
2000
Highly Cited
2000
LAT is essential for Fc(epsilon)RI-mediated mast cell activation.
The linker molecule LAT is a substrate of the tyrosine kinases activated following TCR engagement of T cells. LAT is also… 
2000
2000
Functional Complementation of BLNK by SLP-76 and LAT Linker Proteins*
Recent studies have demonstrated a requirement for the SLP-76 (SH2 domain-containingleukocyte protein of 76 kDa) and LAT (linker… 
Review
2000
Review
2000
Molecular circuitry regulating herpes simplex virus type 1 latency in neurons.
Herpes simplex virus (HSV) type 1 (HSV-1) enters nerve endings during a primary infection, is transported to sensory ganglia, and… 
Highly Cited
1999
Highly Cited
1999
Cutting edge: a role for the adaptor protein LAT in human NK cell-mediated cytotoxicity.
Stimulation of NK cell-mediated cytotoxicity involves the coupling of proximal Src and Syk family protein tyrosine kinases to… 
Highly Cited
1998
Highly Cited
1998
T cell receptor signalling results in rapid tyrosine phosphorylation of the linker protein LAT present in detergent-resistant membrane microdomains.
Stimulation of human T cell line Jurkat results in rapid tyrosine phosphorylation of a 35-38 kDa protein that is found in large… 
1994
1994
Effect of the transcription start region of the herpes simplex virus type 1 latency-associated transcript promoter on expression of productively infected neurons in vivo
It has been previously reported that the latency-associated transcript (LAT) promoter contains a DNA sequence at the LAT… 
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