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OPC 21268

Known as: Acetamide, N-(3-(4-((4-(3,4-dihydro-2-oxo-1(2H)-quinolinyl)-1-piperidinyl)carbonyl)phenoxy)propyl)-, OPC-21268 
 
National Institutes of Health

Papers overview

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Highly Cited
2004
Highly Cited
2004
Arginine vasopressin (AVP) is known to contribute significantly to the pathogenesis of congestive heart failure and hypertension… Expand
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Highly Cited
2004
Highly Cited
2004
Vasopressin receptor subtype(s) responsible for stimulation of insulin release from pancreatic beta cells were investigated by… Expand
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Highly Cited
2000
Highly Cited
2000
Primary cultures of neonatal cardiac myocytes were used to determine both the identity of second messengers that are involved in… Expand
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1999
1999
OBJECTIVE Recent experimental evidence suggests that centrally released arginine vasopressin plays a significant role in brain… Expand
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1996
1996
The effects of the nonpeptide orally effective vasopressin V1 receptor antagonist OPC-21268 were studied in progressive focal… Expand
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Highly Cited
1994
Highly Cited
1994
Rapid right ventricular pacing could induce congestive heart failure in conscious dogs with significant increase in plasma… Expand
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Highly Cited
1994
Highly Cited
1994
To examine whether expression and distribution of aquaporin of collecting duct (AQP-CD) are regulated by vasopressin V2 receptor… Expand
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1994
1994
We studied the hypotensive effects of OPC-21268, an orally effective nonpeptide vasopressin V1 receptor antagonist, in… Expand
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Highly Cited
1993
Highly Cited
1993
SR 49059, a new potent and selective orally active, nonpeptide vasopressin (AVP) antagonist has been characterized in several in… Expand
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Highly Cited
1991
Highly Cited
1991
An orally effective, nonpeptide, vasopressin V1 receptor antagonist, OPC-21268, has been identified. This compound selectively… Expand
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