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O-(chloroacetylcarbamoyl)fumagillol

Known as: [3R-[3alpha,4alpha(2R*,3R*),5beta,6beta]]-5-Methoxy-4-[2-methyl-3-(3-methyl-2-butenyl)oxiranyl]-1-oxaspiro[2.5]oct-6-yl (chloroacetyl)carbamate, 5-methoxy-4-(2-methyl-3-(3-methyl-2-butenyl)oxiranyl)-1-oxaspiro(2,5)oct-6-yl(chloroacetyl) carbamate, (3R,4S,5S,6R)-5-Methoxy-4- [(2R,3R)-2-methyl-3-(3-methyl-2-butenyl) -oxiranyl]-1-oxaspiro [2,5] oct-6-yl(chloroacetyl) Carbamate 
A synthetic analog of fumagillin, an antibiotic isolated from the fungus Aspergillus fumigatus fresenius with antineoplastic activity. TNP-470 binds… 
National Institutes of Health

Related topics

Related topics

7 relations

Narrower (3)

AGM 1470TNP 470caplostatin

Broader (4)

Angiogenesis InhibitorsAntibiotics, AntineoplasticCyclohexanesSesquiterpenes

Papers overview

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2004
2004
Synergistic inhibition of tumor growth and metastasis by combined treatment with TNP-470 and gemcitabine in a human bladder cancer KoTCC-1 model.
PURPOSE TNP-470 (O-(chloroacetylcarbamoyl)fumagillol) is a potent inhibitor of angiogenesis that was reported to enhance… 
1997
1997
Interspecies variability of TNP-470 metabolism, using primary monkey, rat, and dog cultured hepatocytes.
The biotransformation of TNP-470 [O-(chloroacetylcarbamoyl)fumagillol; AGM 1470], a potent in vitro inhibitor of angiogenesis… 
1995
1995
The role of angiogenesis in the tumor growth of Syrian hamster pancreatic cancer cell line HPD-NR.
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