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TNP 470

Known as: TNP-470, TNP470 
A synthetic analog of fumagillin, an antibiotic isolated from the fungus Aspergillus fumigatus fresenius with antineoplastic activity. TNP-470 binds… Expand
National Institutes of Health

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Highly Cited
2005
Highly Cited
2005
The role of angiogenesis during mechanically induced bone formation is incompletely understood. The relationship between the… Expand
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Highly Cited
2004
Highly Cited
2004
Adipose tissue growth has been proposed to involve recruitment of new blood vessels. Here, we test the hypothesis that delivery… Expand
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Highly Cited
2004
Highly Cited
2004
Angiogenesis is crucial for tumor growth. Angiogenesis inhibitors, such as O-(chloracetyl-carbamoyl) fumagillol (TNP-470), are… Expand
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Review
2001
Review
2001
Angiogenesis is a fundamental process in reproduction and wound healing. Under these conditions, neovascularization is tightly… Expand
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Highly Cited
2000
Highly Cited
2000
To reveal the antiangiogenic capability of cancer chemotherapy, we developed an alternative antiangiogenic schedule for… Expand
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Highly Cited
1999
Highly Cited
1999
BACKGROUND Neovascularization within the intima of human atherosclerotic lesions is well described, but its role in the… Expand
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Highly Cited
1999
Highly Cited
1999
The effects of the angiogenic inhibitors endostatin, angiostatin, and TNP-470 on tumor growth dynamics are experimentally and… Expand
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Highly Cited
1997
Highly Cited
1997
The inhibition of new blood vessel formation (angiogenesis) is an effective means of limiting both the size and metastasis of… Expand
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Highly Cited
1994
Highly Cited
1994
The ability of TNP‐470, a synthetic analog of fumagillin which has been described as an anti‐angiogenic agent, to potentiate… Expand
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Highly Cited
1994
Highly Cited
1994
Recently, we reported the anti-angiogenic action along with anti-tumour activity of TNP-470 (AGM-1470). In this study, the effect… Expand
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