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TNP 470

Known as: TNP-470, TNP470 
A synthetic analog of fumagillin, an antibiotic isolated from the fungus Aspergillus fumigatus fresenius with antineoplastic activity. TNP-470 binds… 
National Institutes of Health

Papers overview

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Review
2006
Review
2006
In the absence of disease, microvessels provide vessel wall nutrients to the tunica media, while the intima is fed by oxygen… 
Highly Cited
2005
Highly Cited
2005
The role of angiogenesis during mechanically induced bone formation is incompletely understood. The relationship between the… 
Highly Cited
2004
Highly Cited
2004
Adipose tissue growth has been proposed to involve recruitment of new blood vessels. Here, we test the hypothesis that delivery… 
Highly Cited
2004
Highly Cited
2004
Angiogenesis is crucial for tumor growth. Angiogenesis inhibitors, such as O-(chloracetyl-carbamoyl) fumagillol (TNP-470), are… 
Highly Cited
2004
Review
2001
Review
2001
Highly Cited
2000
Highly Cited
2000
To reveal the antiangiogenic capability of cancer chemotherapy, we developed an alternative antiangiogenic schedule for… 
Highly Cited
1999
Highly Cited
1999
BACKGROUND Neovascularization within the intima of human atherosclerotic lesions is well described, but its role in the… 
Highly Cited
1999
Highly Cited
1999
The effects of the angiogenic inhibitors endostatin, angiostatin, and TNP-470 on tumor growth dynamics are experimentally and…