TNP 470

Known as: TNP-470, TNP470 
A synthetic analog of fumagillin, an antibiotic isolated from the fungus Aspergillus fumigatus fresenius with antineoplastic activity. TNP-470 binds… (More)
National Institutes of Health

Related topics

Related topics

3 relations
AGM 1470

Broader (2)

Angiogenesis InhibitorsO-(chloroacetylcarbamoyl)fumagillol

Papers overview

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Highly Cited
2005
Highly Cited
2005
Inhibition of vessel permeability by TNP-470 and its polymer conjugate, caplostatin.
Angiogenesis inhibitors, such as TNP-470 and the nontoxic HPMA copolymer-TNP-470 (caplostatin), are emerging as a class of… (More)
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Highly Cited
2004
Highly Cited
2004
Targeting angiogenesis with a conjugate of HPMA copolymer and TNP-470
Angiogenesis is crucial for tumor growth. Angiogenesis inhibitors, such as O-(chloracetyl-carbamoyl) fumagillol (TNP-470), are… (More)
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Highly Cited
2004
Highly Cited
2004
Angiogenesis inhibitor, TNP-470, prevents diet-induced and genetic obesity in mice.
Adipose tissue growth has been proposed to involve recruitment of new blood vessels. Here, we test the hypothesis that delivery… (More)
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2001
2001
Angiogenesis inhibitor TNP-470 reduces human pancreatic cancer growth
In this study we investigated the effects of the angiogenesis inhibitor TNP-470 on human pancreatic cancer cells in vitro and in… (More)
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Highly Cited
2000
Highly Cited
2000
Antiangiogenic scheduling of chemotherapy improves efficacy against experimental drug-resistant cancer.
To reveal the antiangiogenic capability of cancer chemotherapy, we developed an alternative antiangiogenic schedule for… (More)
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Review
2000
Review
2000
TNP-470: an angiogenesis inhibitor in clinical development for cancer.
TNP-470, an analogue of fumagillin, has been shown to inhibit angiogenesis in vitro and in vivo. In 1992, TNP-470 entered… (More)
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Highly Cited
1999
Highly Cited
1999
Angiogenesis inhibitors endostatin or TNP-470 reduce intimal neovascularization and plaque growth in apolipoprotein E-deficient mice.
BACKGROUND Neovascularization within the intima of human atherosclerotic lesions is well described, but its role in the… (More)
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Highly Cited
1999
Highly Cited
1999
Tumor development under angiogenic signaling: a dynamical theory of tumor growth, treatment response, and postvascular dormancy.
The effects of the angiogenic inhibitors endostatin, angiostatin, and TNP-470 on tumor growth dynamics are experimentally and… (More)
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Highly Cited
1994
Highly Cited
1994
Cytostatic inhibition of endothelial cell growth by the angiogenesis inhibitor TNP-470 (AGM-1470).
Recently, we reported the anti-angiogenic action along with anti-tumour activity of TNP-470 (AGM-1470). In this study, the effect… (More)
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Highly Cited
1994
Highly Cited
1994
Potentiation of cytotoxic cancer therapies by TNP-470 alone and with other anti-angiogenic agents.
The ability of TNP-470, a synthetic analog of fumagillin which has been described as an anti-angiogenic agent, to potentiate… (More)
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