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TNP 470

Known as: TNP-470, TNP470 
A synthetic analog of fumagillin, an antibiotic isolated from the fungus Aspergillus fumigatus fresenius with antineoplastic activity. TNP-470 binds… 
National Institutes of Health

Related topics

Related topics

3 relations
AGM 1470

Broader (2)

Angiogenesis InhibitorsO-(chloroacetylcarbamoyl)fumagillol

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2006
Review
2006
Neovascularization in human atherosclerosis.
In the absence of disease, microvessels provide vessel wall nutrients to the tunica media, while the intima is fed by oxygen… 
Highly Cited
2005
Highly Cited
2005
Angiogenesis Is Required for Successful Bone Induction During Distraction Osteogenesis
The role of angiogenesis during mechanically induced bone formation is incompletely understood. The relationship between the… 
Highly Cited
2004
Highly Cited
2004
Angiogenesis Inhibitor, TNP-470, Prevents Diet-Induced and Genetic Obesity in Mice
Adipose tissue growth has been proposed to involve recruitment of new blood vessels. Here, we test the hypothesis that delivery… 
Highly Cited
2004
Highly Cited
2004
Targeting angiogenesis with a conjugate of HPMA copolymer and TNP-470
Angiogenesis is crucial for tumor growth. Angiogenesis inhibitors, such as O-(chloracetyl-carbamoyl) fumagillol (TNP-470), are… 
Highly Cited
2004
Highly Cited
2004
Synthesis and biological evaluation of novel curcumin analogs as anti-cancer and anti-angiogenesis agents.
Review
2001
Review
2001
Angiogenesis: regulators and clinical applications.
Highly Cited
2001
Highly Cited
2001
Prevention of fracture healing in rats by an inhibitor of angiogenesis.
Highly Cited
2000
Highly Cited
2000
Antiangiogenic scheduling of chemotherapy improves efficacy against experimental drug-resistant cancer.
To reveal the antiangiogenic capability of cancer chemotherapy, we developed an alternative antiangiogenic schedule for… 
Highly Cited
1999
Highly Cited
1999
Angiogenesis inhibitors endostatin or TNP-470 reduce intimal neovascularization and plaque growth in apolipoprotein E-deficient mice.
BACKGROUND Neovascularization within the intima of human atherosclerotic lesions is well described, but its role in the… 
Highly Cited
1999
Highly Cited
1999
Tumor development under angiogenic signaling: a dynamical theory of tumor growth, treatment response, and postvascular dormancy.
The effects of the angiogenic inhibitors endostatin, angiostatin, and TNP-470 on tumor growth dynamics are experimentally and… 
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