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TNP 470

Known as: TNP-470, TNP470 
A synthetic analog of fumagillin, an antibiotic isolated from the fungus Aspergillus fumigatus fresenius with antineoplastic activity. TNP-470 binds… Expand
National Institutes of Health

Related topics

Related topics

3 relations
AGM 1470

Broader (2)

Angiogenesis InhibitorsO-(chloroacetylcarbamoyl)fumagillol

Papers overview

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Highly Cited
2005
Highly Cited
2005
Angiogenesis Is Required for Successful Bone Induction During Distraction Osteogenesis
The role of angiogenesis during mechanically induced bone formation is incompletely understood. The relationship between the… Expand
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Highly Cited
2004
Highly Cited
2004
Angiogenesis Inhibitor, TNP-470, Prevents Diet-Induced and Genetic Obesity in Mice
Adipose tissue growth has been proposed to involve recruitment of new blood vessels. Here, we test the hypothesis that delivery… Expand
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Highly Cited
2004
Highly Cited
2004
Targeting angiogenesis with a conjugate of HPMA copolymer and TNP-470
Angiogenesis is crucial for tumor growth. Angiogenesis inhibitors, such as O-(chloracetyl-carbamoyl) fumagillol (TNP-470), are… Expand
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Review
2001
Review
2001
Angiogenesis: regulators and clinical applications.
Angiogenesis is a fundamental process in reproduction and wound healing. Under these conditions, neovascularization is tightly… Expand
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Highly Cited
2000
Highly Cited
2000
Antiangiogenic scheduling of chemotherapy improves efficacy against experimental drug-resistant cancer.
To reveal the antiangiogenic capability of cancer chemotherapy, we developed an alternative antiangiogenic schedule for… Expand
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Highly Cited
1999
Highly Cited
1999
Angiogenesis inhibitors endostatin or TNP-470 reduce intimal neovascularization and plaque growth in apolipoprotein E-deficient mice.
BACKGROUND Neovascularization within the intima of human atherosclerotic lesions is well described, but its role in the… Expand
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Highly Cited
1999
Highly Cited
1999
Tumor development under angiogenic signaling: a dynamical theory of tumor growth, treatment response, and postvascular dormancy.
The effects of the angiogenic inhibitors endostatin, angiostatin, and TNP-470 on tumor growth dynamics are experimentally and… Expand
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Highly Cited
1997
Highly Cited
1997
The anti-angiogenic agent fumagillin covalently binds and inhibits the methionine aminopeptidase, MetAP-2.
The inhibition of new blood vessel formation (angiogenesis) is an effective means of limiting both the size and metastasis of… Expand
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Highly Cited
1994
Highly Cited
1994
Potentiation of cytotoxic cancer therapies by TNP‐470 alone and with other anti‐angiogenic agents
The ability of TNP‐470, a synthetic analog of fumagillin which has been described as an anti‐angiogenic agent, to potentiate… Expand
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Highly Cited
1994
Highly Cited
1994
Cytostatic inhibition of endothelial cell growth by the angiogenesis inhibitor TNP-470 (AGM-1470).
Recently, we reported the anti-angiogenic action along with anti-tumour activity of TNP-470 (AGM-1470). In this study, the effect… Expand
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