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Niraparib is an oral poly(adenosine diphosphate [ADP]-ribose) polymerase (PARP) 1/2 inhibitor that has shown clinical… Expand BACKGROUND
Prostate cancer is a heterogeneous disease, but current treatments are not based on molecular stratification. We… Expand BACKGROUND
Olaparib (AZD2281) is an oral poly(adenosine diphosphate [ADP]-ribose) polymerase inhibitor that has shown antitumor… Expand BACKGROUND
The inhibition of poly(adenosine diphosphate [ADP]-ribose) polymerase (PARP) is a potential synthetic lethal… Expand Biochemical experiments over the past 40 years have shown that nucleoside diphosphate(NDP) kinase activity, which catalyzes… Expand Isopentenyl diphosphate (IPP) is the central intermediate in the biosynthesis of isoprenoids, the most ancient and diverse class… Expand Tankyrase, a protein with homology to ankyrins and to the catalytic domain of poly(adenosine diphosphate-ribose) polymerase (PARP… Expand A human gene encoding the c-myc purine-binding transcription factor PuF was identified by screening of a cervical carcinoma cell… Expand There is convincing evidence that cellular prooxidant states--that is, increased concentrations of active oxygen and organic… Expand Vertebrate rod photoreceptors hyperpolarize when illuminated, due to the closing of cation-selective channels in the plasma… Expand