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Nucleoside-Diphosphate Kinase

Known as: Kinases, Nucleoside-Diphosphate, Diphosphate Kinases, Deoxynucleoside, Deoxynucleoside Diphosphate Kinases 
An enzyme that is found in mitochondria and in the soluble cytoplasm of cells. It catalyzes reversible reactions of a nucleoside triphosphate, e.g… Expand
National Institutes of Health

Related topics

Related topics

15 relations
CMPK2 geneIn BloodProcess of secretionantagonists & inhibitors
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Narrower (5)

NBR-A isoenzymeNBR-B isoenzymeNDPK-B protein, humannucleoside diphosphate kinase 2
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Broader (1)

Phosphotransferases, ATP

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2016
Highly Cited
2016
Niraparib Maintenance Therapy in Platinum-Sensitive, Recurrent Ovarian Cancer.
BACKGROUND Niraparib is an oral poly(adenosine diphosphate [ADP]-ribose) polymerase (PARP) 1/2 inhibitor that has shown clinical… Expand
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Highly Cited
2015
Highly Cited
2015
DNA-Repair Defects and Olaparib in Metastatic Prostate Cancer.
BACKGROUND Prostate cancer is a heterogeneous disease, but current treatments are not based on molecular stratification. We… Expand
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Highly Cited
2012
Highly Cited
2012
Olaparib maintenance therapy in platinum-sensitive relapsed ovarian cancer.
BACKGROUND Olaparib (AZD2281) is an oral poly(adenosine diphosphate [ADP]-ribose) polymerase inhibitor that has shown antitumor… Expand
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Highly Cited
2011
Highly Cited
2011
SIRT6 Promotes DNA Repair Under Stress by Activating PARP1
A genome stability regulator integrates DNA repair and stress signaling pathways. Sirtuin 6 (SIRT6) is a mammalian homolog of the… Expand
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Highly Cited
2009
Highly Cited
2009
Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers.
BACKGROUND The inhibition of poly(adenosine diphosphate [ADP]-ribose) polymerase (PARP) is a potential synthetic lethal… Expand
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Highly Cited
2006
Highly Cited
2006
A Topoisomerase IIß-Mediated dsDNA Break Required for Regulated Transcription
Multiple enzymatic activities are required for transcriptional initiation. The enzyme DNA topoisomerase II associates with gene… Expand
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Review
2000
Review
2000
The Human Nm23/Nucleoside Diphosphate Kinases
Biochemical experiments over the past 40 years have shown that nucleoside diphosphate(NDP) kinase activity, which catalyzes… Expand
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Highly Cited
2000
Highly Cited
2000
Isoprenoid biosynthesis: the evolution of two ancient and distinct pathways across genomes.
Isopentenyl diphosphate (IPP) is the central intermediate in the biosynthesis of isoprenoids, the most ancient and diverse class… Expand
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Highly Cited
1998
Highly Cited
1998
Tankyrase, a poly(ADP-ribose) polymerase at human telomeres.
Tankyrase, a protein with homology to ankyrins and to the catalytic domain of poly(adenosine diphosphate-ribose) polymerase (PARP… Expand
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Review
1985
Review
1985
Prooxidant states and tumor promotion.
There is convincing evidence that cellular prooxidant states--that is, increased concentrations of active oxygen and organic… Expand
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