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- Publications
- Influence
Identification of a Biosynthetic Gene Cluster in Rice for Momilactones*
- Kazuhiro Shimura, A. Okada, +10 authors H. Yamane
- Biology, Medicine
- Journal of Biological Chemistry
- 23 November 2007
Rice diterpenoid phytoalexins such as momilactones and phytocassanes are produced in suspension-cultured rice cells treated with a chitin oligosaccharide elicitor and in rice leaves irradiated with… Expand
Fusicoccins are biosynthesized by an unusual chimera diterpene synthase in fungi
- T. Toyomasu, M. Tsukahara, +5 authors T. Sassa
- Biology, Medicine
- Proceedings of the National Academy of Sciences
- 27 February 2007
Fusicoccins are a class of diterpene glucosides produced by the plant-pathogenic fungus Phomopsis amygdali. As modulators of 14-3-3 proteins, fusicoccins function as potent activators of plasma… Expand
In Vivo Conversion of Cellular Prion Protein to Pathogenic Isoforms, as Monitored by Conformation-specific Antibodies*
- T. Yokoyama, K. Kimura, +5 authors S. Itohara
- Biology, Medicine
- The Journal of Biological Chemistry
- 6 April 2001
The central event in prion disease is thought to be conformational conversion of the cellular isoform of prion protein (PrPC) to the insoluble isoform PrPSc. We generated polyclonal and monoclonal… Expand
Diterpene Cyclases Responsible for the Biosynthesis of Phytoalexins, Momilactones A, B, and Oryzalexins A–F in Rice
- Kazuko Otomo, Y. Kanno, +9 authors T. Toyomasu
- Biology, Medicine
- Bioscience, biotechnology, and biochemistry
- 1 January 2004
Rice (Oryza sativa L.) produces diterpene phytoalexins, such as momilactones, oryzalexins, and phytocassanes. Using rice genome information and in vitro assay with recombinant enzymes, we identified… Expand
Effects of combined treatment with rapamycin and cotylenin A, a novel differentiation-inducing agent, on human breast carcinoma MCF-7 cells and xenografts
- T. Kasukabe, J. Okabe‐Kado, N. Kato, T. Sassa, Y. Honma
- Biology, Medicine
- Breast Cancer Research
- 9 November 2005
IntroductionRapamycin, an inhibitor of the serine/threonine kinase target of rapamycin, induces G1 arrest and/or apoptosis. Although rapamycin and its analogues are attractive candidates for cancer… Expand
Biological functions of ent- and syn-copalyl diphosphate synthases in rice: key enzymes for the branch point of gibberellin and phytoalexin biosynthesis.
- Kazuko Otomo, H. Kenmoku, +6 authors T. Toyomasu
- Biology, Medicine
- The Plant journal : for cell and molecular…
- 1 September 2004
Rice (Oryza sativa L.) produces ent-copalyl diphosphate (ent-CDP) and syn-CDP as precursors for several classes of phytoalexins and the phytohormones, gibberellins (GAs). It has recently been shown… Expand
Stabilization of physical RAF/14-3-3 interaction by cotylenin A as treatment strategy for RAS mutant cancers.
- M. Molzan, S. Kasper, +8 authors C. Ottmann
- Biology, Medicine
- ACS chemical biology
- 5 July 2013
One-third of all human cancers harbor somatic RAS mutations. This leads to aberrant activation of downstream signaling pathways involving the RAF kinases. Current ATP-competitive RAF inhibitors are… Expand
Characterization of a Rice Gene Family Encoding Type-A Diterpene Cyclases
- Y. Kanno, Kazuko Otomo, +7 authors T. Toyomasu
- Medicine, Biology
- Bioscience, biotechnology, and biochemistry
- 23 July 2006
We have previously isolated and characterized the rice (Oryza sativa) cDNAs, OsCyc1/OsCPS4, OsCyc2/OsCPS2, OsKS4, OsDTC1/OsKS7, OsDTC2/OsKS8 and OsKS10, which encode cyclases that are responsible for… Expand
Cloning of a Gene Cluster Responsible for the Biosynthesis of Diterpene Aphidicolin, a Specific Inhibitor of DNA Polymerase α
- T. Toyomasu, K. Nakaminami, +7 authors H. Oikawa
- Biology, Medicine
- Bioscience, biotechnology, and biochemistry
- 1 January 2004
The fungal diterpene, aphidicolin, is a well-known specific inhibitor of DNA polymerase α. Terpenoids are an important class of natural products. However, identification of the biosynthetic gene… Expand
Functional Analysis of the Two Interacting Cyclase Domains in ent-Kaurene Synthase from the FungusPhaeosphaeria sp. L487 and a Comparison with Cyclases from Higher Plants*
- H. Kawaide, T. Sassa, Y. Kamiya
- Medicine, Biology
- The Journal of Biological Chemistry
- 28 January 2000
We report here kinetic analysis and identification of the two cyclase domains in a bifunctional diterpene cyclase, Phaeosphaeria ent-kaurene synthase (FCPS/KS). Kinetics of a recombinant FCPS/KS… Expand