No-Observed-Adverse-Effect Level

Known as: NOAEL, Level, No-Observed-Adverse-Effect, No Observed Adverse Effect Level 
The highest dosage administered that does not produce toxic effects.
National Institutes of Health

Related topics

Related topics

2 relations
Acceptable Daily Intake

Broader (1)

No-Observed-Effect Level

Papers overview

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2015
2015
CORAL: model for no observed adverse effect level (NOAEL)
The in vivo repeated dose toxicity (RDT) test is intended to provide information on the possible risk caused by repeated exposure… (More)
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2012
2012
Bisphenol A Impairs Mitochondrial Function in the Liver at Doses below the No Observed Adverse Effect Level
Bisphenol A (BPA) has been reported to possess hepatic toxicity. We investigated the hypothesis that BPA, below the no observed… (More)
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2006
2006
Relation between benchmark dose and no-observed-adverse-effect level in clinical research: effects of daily alcohol intake on blood pressure in Japanese salesmen.
The benchmark dose (BMD) is defined as the dose that corresponds to a specific change in an adverse response compared to the… (More)
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Highly Cited
2003
Highly Cited
2003
Oral toxicity of the cyanobacterial toxin cylindrospermopsin in male Swiss albino mice: determination of no observed adverse effect level for deriving a drinking water guideline value.
The cyanobacterial toxin cylindrospermopsin (CYN) is a frequent contaminant of freshwaters throughout the world, including those… (More)
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Review
2003
Review
2003
Hormesis: the dose-response revolution.
Hormesis, a dose-response relationship phenomenon characterized by low-dose stimulation and high-dose inhibition, has been… (More)
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2003
2003
Confirmation of an acute no-observed-adverse-effect and low-observed-adverse-effect level for copper in bottled drinking water in a multi-site international study.
In a double blind, 3x3 factorial (volumexdose) study, 70 adult females (18-60 years of age) at four different international sites… (More)
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2001
2001
Determination of an acute no-observed-adverse-effect level (NOAEL) for copper in water.
A prospective, double-blind controlled study was designed to determine the acute no-observed-adverse-effect level (NOAEL) of… (More)
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2001
2001
Assessment of the no-observed-adverse-effect level (NOAEL) of gallic acid in mice.
Gallic acid is a naturally occurring plant phenol obtained by the hydrolysis of tannins and is known to show some pharmacological… (More)
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1998
1998
Developmental toxicity of carbendazim: comparison of no-observed-adverse-effect level and benchmark dose approach.
The benchmark dose (BD) approach has been applied to foetal data from four gavage segment II studies (rat studies 1 and 2, rabbit… (More)
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1992
1992
Incidence of developmental defects at the no observed adverse effect level (NOAEL).
Bioassay data from Teratology, Vol. 1 (1968) through Vol. 40 (1990), were utilized which were sufficient to establish no observed… (More)
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