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Assessment of environmental factors affecting male fertility
Postnatal development of testicular enzymes was studied to correlate enzyme activity with particular spermatogenic cell types, and boron-induced infertility was apparently not due to a dominant lethal effect but rather to germinal aplasia. Expand
Natural killer cell activity and quality of life were improved by consumption of a mushroom extract, Agaricus blazei Murill Kyowa, in gynecological cancer patients undergoing chemotherapy.
  • W. Ahn, Dj Kim, +6 authors I. Lee
  • Medicine
  • International journal of gynecological cancer…
  • 1 July 2004
ABMK treatment might be beneficial for gynecological cancer patients undergoing chemotherapy, and chemotherapy-associated side effects such as appetite, alopecia, emotional stability, and general weakness were all improved by ABMK treatment. Expand
Effects of mercury on spermatogenesis studied by velocity sedimentation cell separation and serial mating.
  • I. Lee, R. Dixon
  • Chemistry, Medicine
  • The Journal of pharmacology and experimental…
  • 1 July 1975
Results suggest spermatogenic effects of methylmercury complexes which might have important health consequences in man, and Mercury ion-induced antifertility effects at the dosage used in these experiments are reversible. Expand
Evidence for induction of germinal aplasia in male rats by environmental exposure to boron.
Boron accumulation in testes is associated with progressive germ cell depletion and that the testicular lesion can persist long after toxic exposure to boron has occurred, suggesting that testicular dysfunctions can occur after prolonged exposure to levels of borons which prevail in some areas of the environment. Expand
Protective effects of green tea extracts (polyphenon E and EGCG) on human cervical lesions
  • W. Ahn, J. Yoo, +5 authors I. Lee
  • Medicine
  • European journal of cancer prevention : the…
  • 1 October 2003
It is demonstrated that green tea extracts in a form of ointment and capsule are effective for treating cervical lesions, suggesting that green Tea extracts can be a potential therapy regimen for patients with HPV infected cervical lesions. Expand
Methods to assess reproductive effects of environmental chemicals: studies of cadmium and boron administered orally.
Initial studies, utilizing a variety of methods to assess the reproductive toxicity of environmental substances in male animals, suggest that cadmium and boron at the concentrations and dose regimens tested are without significant reproductive toxicity. Expand
Hormonal regulation of cytochrome P-450-dependent monooxygenase activity and epoxide-metabolizing enzyme activities in testis of hypophysectomized rats.
The result suggests that LH-stimulated induction of testicular AHH and EH activities and P-450 contents may be primarily associated with the interstitial cell compartment, and Leydig cells are target cells of LH. Expand
Prevention of the Cardiotoxic Effects of Adriamycin and Daunomycin in the Isolated Dog Heart 1
Summary In the isolated, blood-perfused dog heart daunomycin (50 mg) or adriamy-cin (50 mg) induced significant increases in coronary perfusion pressure. This effect appeared to be related to theExpand
Developmental patterns of enzymes in mouse testis.
  • R. Shen, I. Lee
  • Chemistry, Medicine
  • Journal of reproduction and fertility
  • 1 November 1976
Study of the activities of hyaluronidase, lactate dehydrogenase isoenzyme-X and the dehydrogenases of sorbitol, alpha-glycerophosphate, glucose-6-phosphate, malate, glyceraldehyde-3-phosphate andExpand
Aspects of testicular toxicity induced by anticancer drugs.
Newer histopathologic techniques were used in combination with sperm head counts (SHC) and serial mating studies to assess different aspects of testicular toxicity to replace SM studies for the assessment of genotoxicity (Proc). Expand