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Nimustine

Known as: Urea, N'-((4-amino-2-methyl-5-pyrimidinyl)methyl)-N-(2-chloroethyl)-N-nitroso-, N'-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-N-(2-chloroethyl)-N-nitrosourea, 3-((4-Amino-2-Methyl-5-Pyrimidinyl)Methyl)-1-(2-Chloroethyl)-1-Nitrosourea 
Antineoplastic agent especially effective against malignant brain tumors. The resistance which brain tumor cells acquire to the initial effectiveness… Expand
National Institutes of Health

Papers overview

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Highly Cited
2005
Highly Cited
2005
SummaryWe analysed long-term follow-up results of 175 patients with malignant glioma (110 glioblastoma and 65 anaplastic… Expand
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Review
2003
Review
2003
PURPOSE The role of chemotherapy in the primary treatment of malignant glioma remains controversial. The results from the German… Expand
Highly Cited
2000
Highly Cited
2000
O(6)-methylguanine-DNA methyltransferase plays vital roles in preventing induction of mutations and cancer as well as cell death… Expand
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Highly Cited
1997
Highly Cited
1997
Steroids are commonly administered for the control of edema, mass effect, and side effects from therapy to patients with… Expand
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Highly Cited
1993
Highly Cited
1993
To determine whether the apoptotic cell death induced by anti-cancer agents could be inhibited by bcl-2, we established a bcl-2… Expand
Highly Cited
1991
Highly Cited
1991
A controlled randomized study was carried out to evaluate the effects of chemotherapy in patients with brain metastases from lung… Expand
Highly Cited
1990
Highly Cited
1990
One hundred nine newly treated patients with advanced neuroblastoma were entered in this study between January 1985 and May 1989… Expand
Highly Cited
1990
Highly Cited
1990
The nitrosoureas BCNU, CCNU, ACNU, and Fotemustine covalently deactivate thioredoxin reductase, glutathione reductase and… Expand
Highly Cited
1986
Highly Cited
1986
A randomized clinical study of irradiation and irradiation combined with ACNU in the treatment of malignant gliomas was performed… Expand
Highly Cited
1985
Highly Cited
1985
  • J. Barrett
  • British journal of cancer
  • 1985
  • Corpus ID: 8252436
Previous studies have suggested that 1-(4-amino-2-methylpyrimidine-5-yl)-methyl-3-(2-chloroethyl) -3-nitrosoureahydrochloride… Expand
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