Nimustine

Known as: Urea, N'-((4-amino-2-methyl-5-pyrimidinyl)methyl)-N-(2-chloroethyl)-N-nitroso-, N'-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-N-(2-chloroethyl)-N-nitrosourea, 3-((4-Amino-2-Methyl-5-Pyrimidinyl)Methyl)-1-(2-Chloroethyl)-1-Nitrosourea 
Antineoplastic agent especially effective against malignant brain tumors. The resistance which brain tumor cells acquire to the initial effectiveness… (More)
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2004
2004
Inhibition of angiogenesis is an important new treatment modality for malignancies, including gliomas. Vascular endothelial… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
2000
2000
Drug resistance is a major clinical problem in the chemotherapy of human gliomas. The multidrug resistance-associated protein… (More)
  • table 1
  • figure 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
2000
2000
O(6)-methylguanine-DNA methyltransferase plays vital roles in preventing induction of mutations and cancer as well as cell death… (More)
  • figure 2
  • figure 1
  • figure 3
  • table 1
  • figure 4
Is this relevant?
1997
1997
Steroids are commonly administered for the control of edema, mass effect, and side effects from therapy to patients with… (More)
Is this relevant?
1996
1996
The DNA repair protein O6-methylguanine-DNA methyltransferase (MGMT) removes alkyl groups from the O6 position of guanine in DNA… (More)
Is this relevant?
Highly Cited
1993
Highly Cited
1993
To determine whether the apoptotic cell death induced by anti-cancer agents could be inhibited by bcl-2, we established a bcl-2… (More)
Is this relevant?
1992
1992
The aim of this study was to optimize the experimental conditions of the MTT assay for primary cultures of human brain tumors… (More)
  • figure 1
  • figure 2
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
1991
1991
A controlled randomized study was carried out to evaluate the effects of chemotherapy in patients with brain metastases from lung… (More)
Is this relevant?
1990
1990
To elucidate the mechanism(s) of cisplatin resistance, we have characterized a human non-small cell lung cancer cell line (PC-9… (More)
Is this relevant?
1988
1988
Based on a pharmacokinetic model proposed by Jusko, which assumes that the cell killing action of cell cycle phase-non-specific… (More)
  • figure 3
  • figure 1
  • figure 6
  • figure 4
  • figure 7
Is this relevant?