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Nimustine

Known as: Urea, N'-((4-amino-2-methyl-5-pyrimidinyl)methyl)-N-(2-chloroethyl)-N-nitroso-, N'-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-N-(2-chloroethyl)-N-nitrosourea, 3-((4-Amino-2-Methyl-5-Pyrimidinyl)Methyl)-1-(2-Chloroethyl)-1-Nitrosourea 
Antineoplastic agent especially effective against malignant brain tumors. The resistance which brain tumor cells acquire to the initial effectiveness… 
National Institutes of Health

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14 relations

Narrower (5)

AAAP protocolCE-AVN protocolDAV protocolNidran

Broader (1)

Antineoplastic Agents
In BloodNCIt Antineoplastic Agent Terminologyagonistsanalogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2005
Highly Cited
2005
Long-term follow-up results of 175 patients with malignant glioma: Importance of radical tumour resection and postoperative adjuvant therapy with interferon, ACNU and radiation
SummaryWe analysed long-term follow-up results of 175 patients with malignant glioma (110 glioblastoma and 65 anaplastic… 
Highly Cited
2004
Highly Cited
2004
Cell killing action of cell cycle phase-non-specific antitumor agents is dependent on concentration-time product
SummaryBased on a pharmacokinetic model proposed by Jusko, which assumes that the cell killing action of cell cycle phase-non… 
Highly Cited
2003
Highly Cited
2003
O6‐methylguanine‐DNA methyltranspherase gene expression in gliomas by means of real‐time quantitative RT‐PCR and clinical response to nitrosoureas
O6‐methylguanine‐DNA methyltransferase (MGMT) mRNA expressions were examined in 100 neuroepithelial tumors by real‐time… 
Highly Cited
2002
Highly Cited
2002
Hematoprotection and enrichment of transduced cells in vivo after gene transfer of MGMTP140K into hematopoietic stem cells
The overexpression of mutant forms of O6-methylguanine-DNA-methyltransferase (MGMT), resistant to the MGMT inhibitor O6… 
2000
2000
Randomized Comparison of Intra-arterial Versus Intravenous Infusion of ACNU for Newly Diagnosed Patients with Glioblastoma
This prospective randomized trial was performed to compare the effectiveness of intra-arterial ACNU with intravenous ACNU in… 
1999
1999
Treatment of Intracranial Nongerminomatous Germ-cell Tumor by High-dose Chemotherapy and Autologous Stem-cell Rescue
Nongerminomatous germ-cell tumor (NGGCT) in the central nervous system (CNS) is still highly lethal. The present study evaluated… 
1994
1994
Artificial control of nuclear translocation of DNA repair methyltransferase.
1987
1987
Influence of modes of ACNU administration on tissue and blood drug concentration in malignant brain tumors.
The water-soluble nitrosourea compound ACNU is also lipid-soluble at normal physiological pH levels. It lacks toxic effects on… 
1986
1986
[Treatment of malignant brain tumors with slowly releasing anticancer drug-polymer composites].
The purpose of this study is to present the methodology and results of a clinical trial of local chemotherapy of malignant brain… 
1986
1986
Evaluation of response rates to various antitumor agents of human gastric tumors implanted in nude mouse.
To ascertain the clinical predictability and, in the long run, the usefulness of the human tumor/nude mouse model as a screening… 
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