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Nimustine

Known as: Urea, N'-((4-amino-2-methyl-5-pyrimidinyl)methyl)-N-(2-chloroethyl)-N-nitroso-, N'-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-N-(2-chloroethyl)-N-nitrosourea, 3-((4-Amino-2-Methyl-5-Pyrimidinyl)Methyl)-1-(2-Chloroethyl)-1-Nitrosourea 
Antineoplastic agent especially effective against malignant brain tumors. The resistance which brain tumor cells acquire to the initial effectiveness… 
National Institutes of Health

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Narrower (5)

AAAP protocolCE-AVN protocolDAV protocolNidran

Broader (1)

Antineoplastic Agents
In BloodNCIt Antineoplastic Agent Terminologyagonistsanalogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2004
Review
2004
Experimental and clinical effect of ACNU in Japan, with emphasis on small-cell carcinoma of the lung
SummaryThe experimental and clinical effects of ACNU so far recorded in Japan are reviewed. ACNU was highly effective in leukemia… 
1989
1989
Responses of pineocytoma to radiation therapy and chemotherapy--report of two cases.
Pineal parenchymal tumors are so rare that their responses to radiation and/or chemotherapy are not well known. Two cases of… 
1987
1987
Specific induction of ACNU-resistance in V79 Chinese hamster cells and C6 rat glioma cells.
The antitumor compound ACNU (1-(4-amino-2-methyl-5-pyrimidinyl)methyl-3-(2-chloroethyl)-3-nitroso ure a hydrochloride) is widely… 
1986
1986
Evaluation of response rates to various antitumor agents of human gastric tumors implanted in nude mouse.
To ascertain the clinical predictability and, in the long run, the usefulness of the human tumor/nude mouse model as a screening… 
1986
1986
Interactions of human fibroblast interferon with chemotherapeutic agents and radiation against human gliomas in nude mice.
The growth inhibitory effects of the combination of beta-interferon (beta-IFN) and conventional anticancer drugs such as… 
1985
1985
Central nervous system toxicity and cerebrospinal fluid pharmacokinetics of intraventricular 3-[(4-amino-2-methyl-5-pyrimidinyl)ethyl]-1-(2-chloroethyl)-1-nitro soureas and other nitrosoureas in…
The central nervous system toxicity and cerebrospinal fluid (CSF) pharmacokinetics of 3-[(4-amino-2-methyl-5-pyrimidinyl)ethyl]-1… 
1985
1985
[ACNU delivery to malignant glioma tissue by osmotic blood brain barrier modification with intracarotid infusion of hyperosmoral mannitol].
Drug delivery to the tumor has been one of the major subjects in the field of brain tumor chemotherapy because of blood brain… 
1983
1983
[Treatment schedule of combination using radiation and ACNU in the experimental brain tumors].
This study was undertaken to identify the combined effect of ACNU treatment and irradiation in a rat brain tumor model. The brain… 
1979
1979
[A consideration on pharmacokinetics of a new water-soluble anti-tumor nitrosourea, ACNU, in patients with malignant brain tumor (author's transl)].
1974
1974
Effect of 1-(4-amino-2-methylpyrimidin-5-yl)methyl-3-(2-chloroethyl)-3-nitrosourea hydrochloride on leukemia L-1210(Communication)
In recent years, antitumor effect of nitrosourea derivatives such as 1,3-bis(2-chloroethyl)-1-nitrosourea, 1-(2-chloroethyl-3… 
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