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Nimustine
Known as:
Urea, N'-((4-amino-2-methyl-5-pyrimidinyl)methyl)-N-(2-chloroethyl)-N-nitroso-
, N'-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-N-(2-chloroethyl)-N-nitrosourea
, 3-((4-Amino-2-Methyl-5-Pyrimidinyl)Methyl)-1-(2-Chloroethyl)-1-Nitrosourea
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Antineoplastic agent especially effective against malignant brain tumors. The resistance which brain tumor cells acquire to the initial effectiveness…
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National Institutes of Health
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Related topics
Related topics
14 relations
Narrower (5)
AAAP protocol
CE-AVN protocol
DAV protocol
Nidran
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Broader (1)
Antineoplastic Agents
In Blood
NCIt Antineoplastic Agent Terminology
agonists
analogs & derivatives
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Review
2004
Review
2004
Experimental and clinical effect of ACNU in Japan, with emphasis on small-cell carcinoma of the lung
N. Saijo
,
H. Niitani
Cancer Chemotherapy and Pharmacology
2004
Corpus ID: 10710258
SummaryThe experimental and clinical effects of ACNU so far recorded in Japan are reviewed. ACNU was highly effective in leukemia…
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1989
1989
Responses of pineocytoma to radiation therapy and chemotherapy--report of two cases.
K. Sakoda
,
T. Uozumi
,
+4 authors
T. Nakahara
Neurologia medico-chirurgica
1989
Corpus ID: 39338919
Pineal parenchymal tumors are so rare that their responses to radiation and/or chemotherapy are not well known. Two cases of…
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1987
1987
Specific induction of ACNU-resistance in V79 Chinese hamster cells and C6 rat glioma cells.
Yukio Horie
,
Kenji Arai
,
Shunro Endoh
,
T. Kuroki
,
A. Takaku
Journal of Neurosurgery
1987
Corpus ID: 24192347
The antitumor compound ACNU (1-(4-amino-2-methyl-5-pyrimidinyl)methyl-3-(2-chloroethyl)-3-nitroso ure a hydrochloride) is widely…
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1987
1987
Cell cycle perturbation of cultured C6 glioma cells following short-term contact with a low dose of ACNU.
S. Genka
,
N. Shitara
,
Y. Tsujita
,
Y. Kosugi
,
Y. Wu
,
K. Takakura
Cytometry
1987
Corpus ID: 34951619
The purpose of this study was to investigate the cell cycle perturbation of cultured C6 rat glioma cells induced by 1-(4-amino-2…
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1986
1986
Evaluation of response rates to various antitumor agents of human gastric tumors implanted in nude mouse.
M. Inaba
,
T. Tashiro
,
+6 authors
T. Nomura
Japanese journal of cancer research : Gann
1986
Corpus ID: 22890261
To ascertain the clinical predictability and, in the long run, the usefulness of the human tumor/nude mouse model as a screening…
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1985
1985
Central nervous system toxicity and cerebrospinal fluid pharmacokinetics of intraventricular 3-[(4-amino-2-methyl-5-pyrimidinyl)ethyl]-1-(2-chloroethyl)-1-nitro soureas and other nitrosoureas in…
V. Levin
,
D. Byrd
,
J. Campbell
,
D. D. Giannini
,
J. K. Borcich
,
R. Davis
Cancer Research
1985
Corpus ID: 44268019
The central nervous system toxicity and cerebrospinal fluid (CSF) pharmacokinetics of 3-[(4-amino-2-methyl-5-pyrimidinyl)ethyl]-1…
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1985
1985
Potentiation by vitamin A of the action of anticancer agents against murine tumors.
M. Nakagawa
,
T. Yamaguchi
,
+5 authors
M. Kuwano
Japanese journal of cancer research : Gann
1985
Corpus ID: 40143762
Combinations of retinol palmitate (RP) and six different anticancer agents were examined to determine their effects on the life…
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1983
1983
[Treatment schedule of combination using radiation and ACNU in the experimental brain tumors].
S. Kaneko
,
N. Allen
,
N. Clendenon
,
M. Kartha
Neurologia medico-chirurgica
1983
Corpus ID: 46381705
This study was undertaken to identify the combined effect of ACNU treatment and irradiation in a rat brain tumor model. The brain…
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1978
1978
Antitumor activity of 3-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-1-(2-chloroethyl)-1-nitrosourea hydrochloride in a variety of experimental tumors.
F. Shimizu
,
M. Arakawa
Gan
1978
Corpus ID: 10445386
A water-soluble nitrosourea, 3-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-1-(2-chloroethyl)-1-nitrosourea hydrochloride (ACNU, NSC…
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1974
1974
Effect of 1-(4-amino-2-methylpyrimidin-5-yl)methyl-3-(2-chloroethyl)-3-nitrosourea hydrochloride on leukemia L-1210(Communication)
M. Arakawa
1974
Corpus ID: 82653829
In recent years, antitumor effect of nitrosourea derivatives such as 1,3-bis(2-chloroethyl)-1-nitrosourea, 1-(2-chloroethyl-3…
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