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Nimustine

Known as: Urea, N'-((4-amino-2-methyl-5-pyrimidinyl)methyl)-N-(2-chloroethyl)-N-nitroso-, N'-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-N-(2-chloroethyl)-N-nitrosourea, 3-((4-Amino-2-Methyl-5-Pyrimidinyl)Methyl)-1-(2-Chloroethyl)-1-Nitrosourea 
Antineoplastic agent especially effective against malignant brain tumors. The resistance which brain tumor cells acquire to the initial effectiveness… Expand
National Institutes of Health

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Highly Cited
2005
Highly Cited
2005
SummaryWe analysed long-term follow-up results of 175 patients with malignant glioma (110 glioblastoma and 65 anaplastic… Expand
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Highly Cited
2004
Highly Cited
2004
OBJECTIVEO6-Methylguanine-deoxyribonucleic acid methyltransferase (MGMT) is a deoxyribonucleic acid repair protein associated… Expand
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Highly Cited
2002
Highly Cited
2002
The overexpression of mutant forms of O6-methylguanine-DNA-methyltransferase (MGMT), resistant to the MGMT inhibitor O6… Expand
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Highly Cited
1997
Highly Cited
1997
Steroids are commonly administered for the control of edema, mass effect, and side effects from therapy to patients with… Expand
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Highly Cited
1993
Highly Cited
1993
To determine whether the apoptotic cell death induced by anti-cancer agents could be inhibited by bcl-2, we established a bcl-2… Expand
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Highly Cited
1991
Highly Cited
1991
Abstract A controlled randomized study was carried out to evaluate the effects of chemotherapy in patients with brain metastases… Expand
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Highly Cited
1990
Highly Cited
1990
One hundred nine newly treated patients with advanced neuroblastoma were entered in this study between January 1985 and May 1989… Expand
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Highly Cited
1990
Highly Cited
1990
The nitrosoureas BCNU, CCNU, ACNU, and Fotemustine covalently deactivate thioredoxin reductase, glutathione reductase and… Expand
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Highly Cited
1986
Highly Cited
1986
A randomized clinical study of irradiation and irradiation combined with ACNU in the treatment of malignant gliomas was performed… Expand
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Highly Cited
1985
Highly Cited
1985
  • J. Barrett
  • British journal of cancer
  • 1985
  • Corpus ID: 8252436
Previous studies have suggested that 1-(4-amino-2-methylpyrimidine-5-yl)-methyl-3-(2-chloroethyl) -3-nitrosoureahydrochloride… Expand
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