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An improved rat brain-tumor model.
The widely used intracerebral tumor implantation method by freehand injection into parietal or hippocampal areas of the rat brain has proven inadequate for reliable experimental therapeutic studies, but is satisfactory for radiation and chemotherapeutic trials in which survival time as an index of tumor size may be used an end point.
CLINICAL CRITERIA OF BRAIN DEATH *
- N. Allen, J. Burkholder, John Comiscioni
- Medicine, PsychologyAnnals of the New York Academy of Sciences
- 1 November 1978
The snout and jaw reflexes were the two cephalic reflexes most likely to persist in presumptive brain death and to have low phi coefficients, and clinical signs recommended as diagnostic criteria include: coma, apnea, and the absence of the light, vestibular, oculocephalic and corneal reflexes.
The morphogenesis of hydranencephaly.
Further observations on the nature of prosopagnosia
CYTOCHROME OXIDASE IN HUMAN BRAIN TUMOURS *
- N. Allen
- MedicineJournal of neurochemistry
- 1 December 1957
The aim has been to estimate the activity of an enzyme important to biological oxidations in a series of gliomas of varying types and degrees of malignancy, correlating such data where possible with histological characteristics, using the Linderstrom-Lang technique of quantitative histochemistry.
A mitochondrial lesion in experimental spinal cord trauma.
A drop in cytochrome oxidase activities to approximately 50% of normal value was found as early as 15 minutes post-trauma, with greatest decrease at the trauma center and lesser effects at successive distances.
CSF β-Glucuronidase Assay in the Diagnosis of Neoplastic Meningitis
The clinical value of CSF β-glucuronidase assay in the differential diagnosis of chronic meningitis has been investigated over the past 20 years and it is concluded that this assay should be considered as a gold-standard test for this diagnosis.
The effect of dimethyl sulfoxide on gray matter injury in experimental spinal cord trauma.
A slight but non-significant increase in the amount of hemorrhage was noted in gray matter at the trauma site following treatment with dimethyl sulfoxide, and the agent resulted in an increase in cytochrome oxidase activities in nontraumatized control gray matter.
Inhibition of Na+-K+-activated ATPase activity following experimental spinal cord trauma.
The specific activity of the membrane-bound enzyme, Na+-K+-activated adenosine triphosphatase (ATPase) has been shown to be decreased following experimental impact injury to the spinal cord in dogs, and was most prominent in the central core of the traumatized segments of spinal cord.