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Evaluation of antitumor activity in a human breast tumor/nude mouse model with a special emphasis on treatment dose
Eight lines of human breast tumors implanted in nude mice were treated with various antitumor agents at two different doses, maximum tolerated doses (MTD) and rational doses (RD) that wereExpand
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Pharmacokinetic Approach to Rational Therapeutic Doses for Human Tumor‐bearing Nude Mice
To improve clinical predictability from therapeutic results of various antitnmor agents in human tumor/nude mouse models it seems to be important to use a dose pharmacokinetically equivalent to theExpand
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Antitumor effects of IST-622, a novel synthetic derivative of chartreusin, against murine and human tumor lines following oral administration
The antitumor effects of 6-O-(3-ethoxypropionyl)-3′,4′-O-exo-benzylidenechartreusin (IST-622), a new synthetic derivative of chartreusin (CT), were investigated. Following oral administration,Expand
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Responsiveness of human lung cancer/nude mouse to antitumor agents in a model using clinically equivalent doses
SummaryThe responses of 14 lines of human lung cancer xenografts in BALB/c-nu/nu mice to eight known antitumor agents were investigated. These xenografts consisted of four small-cell carcinomasExpand
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Evaluation of response rates to various antitumor agents of human gastric tumors implanted in nude mouse.
To ascertain the clinical predictability and, in the long run, the usefulness of the human tumor/nude mouse model as a screening tool for antitumor agents, it seems particularly important to use asExpand
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Cytotoxicity and Antitumor Activities of Fungal Bis (naphtho-γ-pyrone) Derivatives
Cytotoxicities of twenty-seven fungal naphtho-γ-pyrone derivatives to KB cells were examined. Chaetochromins A-D (1-4) and ustilaginoidins D (10) and E (11) exhibited strong effects and theExpand
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Responsiveness of Human Gastric Tumors Implanted in Nude Mice to Clinically Equivalent Doses of Various Antitumor Agents
To reproduce clinical effects of various antitumor agents in the human tumor/nude mouse model, we investigated the responsiveness of 11 lines of human gastric tumor xenografts to doses of the agentsExpand
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Characterization of Acquired Resistance to cis‐Diamminedichloroplatinum(II) in Mouse Leukemia Cell Lines
  • T. Tashiro, Y. Satô
  • Biology, Medicine
  • Japanese journal of cancer research : Gann
  • 1 February 1992
We have established in vivo cisplatin‐resistant mouse leukemia cell lines, L‐1210/DDP and P388/ DDP, in order to elucidate the mechanism of acquired resistance to cisplatin. Resistance indices wereExpand
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Synthesis and antitumor activity of tropolone derivatives. 1
: Treatment of tropolones with benzaldehyde diethyl acetals gave monotropolone (12) and bistropolone (13) derivatives at the benzylic position, whereas the related 1-ethoxyisochroman and the diethylExpand
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A new orally active antitumor 1R,2R-cyclohexanediamine-platinum(IV) complex: trans-(n-valerato)chloro(1R,2R-cyclohexanediamine) (oxalato)platinum(IV)
Purpose: The authors have previously reported that trans-bis(n-valerato)(1R,2R-cyclohexanediamine) (oxalato)platinum(IV) (C5-OHP), an oxaliplatin derivative, is an orally active antitumor agent in anExpand
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