Skip to search formSkip to main contentSkip to account menu

Nefopam

Known as: 1H-2,5-Benzoxazocine, 3,4,5,6-tetrahydro-5-methyl-1-phenyl-, Nefopam [Chemical/Ingredient] 
Non-narcotic analgesic chemically similar to ORPHENADRINE. Its mechanism of action is unclear. It is used for the relief of acute and chronic pain… 
National Institutes of Health

Related topics

Related topics

13 relations

Narrower (4)

AcupanAjanN-desmethylnefopamSilentan Nefopam

Broader (1)

Analgesics, Non-Narcotic
In BloodNefopam Hydrochlorideagonistsanalogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2007
Review
2007
Overview of adverse reactions to nefopam: an analysis of the French Pharmacovigilance database
Nefopam is widely used for the relief of moderate acute pain. Its safety profile remains to be specified. The objective of the… 
Highly Cited
2006
Highly Cited
2006
The Effect of Nefopam on Morphine Overconsumption Induced by Large-Dose Remifentanil During Propofol Anesthesia for Major Abdominal Surgery
Opioids may activate pain facilitatory systems opposing analgesia. We investigated whether large-dose remifentanil given during… 
Review
2002
Review
2002
Respiratory problems in advanced cancer
Respiratory problems are an important issue in the palliative care setting, not only from a diagnostic and therapeutic point of… 
2001
2001
Nefopam reduces thermal hypersensitivity in acute and postoperative pain models in the rat.
The activity of nefopam, a centrally acting compound, not structurally related to other analgesics, was examined in acute and… 
Review
1995
Review
1995
Adverse reactions associated with nefopam.
AIM To review postmarketing experience of adverse reactions associated with nefopam. METHODS Spontaneous reports of adverse… 
Highly Cited
1990
Highly Cited
1990
Postoperative nefopam and diclofenac Evaluation of their morphine‐sparing effect after upper abdominal surgery
The aim of the study was to assess the relative morphine‐sparing effects of nefopam and diclofenac when used singly or in… 
1987
1987
Antinociceptive effects of (±)‐, (+)‐ and (‐)‐nefopam in mice
The antinociceptive activity of (±)‐, (+)‐ and (‐)‐nefopam in mice has been examined using the hot‐plate, formalin and tail‐flick… 
1983
1983
Involvement of biogenic amines with the mechanisms of novel analgesics
Highly Cited
1976
Highly Cited
1976
Molecular geometry of inhibitors of the uptake of catecholamines and serotonin in synaptosomal preparations of rat brain.
Several compounds of relatively rigid molecular structure have been found to exert strong blockade of monoamine uptake by… 
1975
1975
Respiratory effects of nefopam
Arespiratory study has been done to compare the respiratory effects of a potent new analgesic, nefopam, to morphine. Morphine was… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)