Nefopam Hydrochloride

Known as: 3,4,5,6-Tetrahydro-5-Methyl-1-Phenyl-1H-2,5-Benzoxazocine Hydrochloride, Fenazoxine, Hydrochloride, Nefopam

The hydrochloride salt form of nefopam, a centrally-acting, non-opioid benzoxazocine with analgesic activity. The mechanism of action through which…

National Institutes of Health

Papers overview

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2017

In this study, molecular binding affinity was investigated for Nefopam analogues (NFs), a functionalized benzoxazocine, with…

2003

Nefopam hydrochloride is a non-narcotic analgesic used parenterally and orally as a racemic mixture for the relief of…

1990

A stability-indicating reversed-phase high performance liquid chromatographic method was developed for the detection of nefopam…

1989

Equatorial and axial N-methyl diastereomers of the analgesic drug nefopam hydrochloride were differentiated using a hypothetical…

1986

The solid state structures of (+/-)- and (+)-nefopam hydrochloride (3,4,5,6-tetrahydro-5-methyl-1-phenyl-1H-2,5-benzoxazocine…

1983

The adsorption of nefopam hydrochloride to two different charcoals was studied in vitro at pH 1.2 and 7.4. Both forms of…

1982

SummaryThe analgesic potency of nefopam was compared to that of morphine, pentazocine and pethidine, double-blind in 200 patients…

1979

The analgesic efficacy of 60 and 120 mg nefopam hydrochloride was compared to 650 mg aspirin and placebo in a double-blind single…

1976

Two dose-levels of nefopam hydrochloride (i.e. 30 mg and 60 mg) were compared with two dose-levels of aspirin (i.e. 300 mg and…

1969

1 . The action of fenazoxine, a cyclized analogue of orphenadrine, has been studied on peripheral tissues innervated by…