The Clinical Analgesic Efficacy of Oral Nefopam Hydrochloride

  title={The Clinical Analgesic Efficacy of Oral Nefopam Hydrochloride},
  author={R. I. H. Wang and E Waite},
  journal={The Journal of Clinical Pharmacology},
  • R. WangE. Waite
  • Published 1 July 1979
  • Medicine, Psychology
  • The Journal of Clinical Pharmacology
The analgesic efficacy of 60 and 120 mg nefopam hydrochloride was compared to 650 mg aspirin and placebo in a double-blind single-dose study. Oral doses were administered to 120 patients suffering from acute postsurgical or fracture pain. All active medications demonstrated analgesic activity in comparison to placebo. Patients on 120 mg nefopam obtained the greatest degree of analgesia. Side effects were minor and did not interfere with the course of therapy. The incidence of side effects… 

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