Respiratory effects of nefopam

  title={Respiratory effects of nefopam},
  author={J. C. Gasser and J. W. Bellville},
  journal={Clinical Pharmacology \& Therapeutics},
Arespiratory study has been done to compare the respiratory effects of a potent new analgesic, nefopam, to morphine. Morphine was a potent respiratory depressant at therapeutic dosage while nefopam was not. 

The effects of nefopam on blood acid‐base status in the rabbit: interactions with morphine in the mouse and rabbit

Nefopam, a non‐narcotic analgesic, had only minor effects upon the blood pH, Pco2 and standard bicarbonate of the conscious rabbit, and when nefopam was administered in conjunction with morphine the increase in P co2 was greater than with morphine alone.

The Analgesic and Hypothermic Effects of Nefopam, Morphine, Aspirin, Diphenhydramine, and Placebo

No statistically significant differences in pain intensity or relief were seen for nefopam (Acupan), diphenhydramine (Benadryl), aspirin, or placebo despite a numerically higher score for ne fopam despite a unexpectantly high placebo response.


The present study assessed the effects of two oral doses of nefopam on the ventilatory response to CO2, an analgesic whose structure is unrelated to either the opioid or antipyretic analgesics.

Rediscovery of Nefopam for the Treatment of Neuropathic Pain

The recently discovered dual analgesic mechanisms of action, namely, descending pain modulation by triple neurotransmitter reuptake inhibition similar to antidepressants, and inhibition of long-term potentiation mediated by NMDA from the inhibition of calcium influx like gabapentinoid anticonvulsants or blockade of voltage-sensitive sodium channels like carbamazepine, enable NFP to be used as a therapeutic agent to treat neuropathic pain.

Nefopam: A Review of its Pharmacological Properties and Therapeutic Efficacy

Nefopam is a non-narcotic analgesic not structurally related to other analgesic drugs, and when appropriate dose ratios were compared in short term studies it was shown to produce analgesia comparable to that with the oral analgesics aspirin, dextropropoxyphene and pentazocine, as well as that with ‘moderate’ doses of parenteral morphine, pethidine and pentacine.

A Comparison of the Analgesic Effect of Intramuscular Nefopam and Morphine in Patients with Postoperative Pain

Nefopam is chemically Gasse13 recognized that the drug had an unrelated to any known class of analgesics analgesic effect in his human experimental and is pharmacologically distinct from model for muscle relaxant activity.

Oral nefopam and aspirin

Treatment effects were consistent and indicative of good dose response to both active medications, and pain relief scores were more variable but were generally in accordance with SPID values.

A comparison of a new analgesic, nefopam hydrochloride, with morphine sulphate, pentazocine and pethidine hydrochloride in post-operative pain

It is suggested that nefopam is a sufficiently potent analgesic agent to control post-operative pain, with a relatively low incidence of side-effects.

Comparison of the Analgesic Dose‐Effect Relationships of Nefopam and Oxycodone in Postoperative Pain

Drowsiness and a decrease in the respiratory rate were the principal side‐effects of oxycodone, whereas tachycardia, restlessness, sweating and nausea were more frequent after nefopam.



The interaction of morphine and d‐tubocurarine on respiration and grip strength in man

In healthy male volunteers, morphine in combination with d‐tubocurarine produces a greater decrease in responsiveness to end expiratory carbon dioxide than does morphine alone.

The respiratory effects of codeine and morphine in man

A controlled study was carried out in human volunteers to compare the respiratory effects of codeine and morphine administered intramuscularly and codeine administered orally and intram1lScularly and it was concluded that similar degrees of respiratory depression are induced.

Comparative analgesie studies of nefopam and morphine, CUN

  • 1975

The respiratory and subjeetive effeets of pentazoeine

  • 1965

Effeet of methotrimeprazine on respiration

  • 1963

The respiratory and subjeetive effeets of pentazoeine, CUN

  • 1965

A elinieal method for assessing the ventilatory response to earbon dioxide

  • Australas. Ann. Med
  • 1967

A elinieal method for assessing the ventilatory response to earbon dioxide, Australas

  • Ann. Med
  • 1967

The interaetion of morphine and d- tuboeurarine on respiration and grip strength in man, CUN

  • 1964

Comparative analgesie studies of nefopam and morphine

  • 1975