Respiratory effects of nefopam

@article{Gasser1975RespiratoryEO,
  title={Respiratory effects of nefopam},
  author={J. C. Gasser and J. W. Bellville},
  journal={Clinical Pharmacology \& Therapeutics},
  year={1975},
  volume={18}
}
Arespiratory study has been done to compare the respiratory effects of a potent new analgesic, nefopam, to morphine. Morphine was a potent respiratory depressant at therapeutic dosage while nefopam was not. 
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    The effects of nefopam on blood acid‐base status in the rabbit: interactions with morphine in the mouse and rabbit
    TLDR
    Nefopam, a non‐narcotic analgesic, had only minor effects upon the blood pH, Pco2 and standard bicarbonate of the conscious rabbit, and when nefopam was administered in conjunction with morphine the increase in P co2 was greater than with morphine alone. Expand
    The Analgesic and Hypothermic Effects of Nefopam, Morphine, Aspirin, Diphenhydramine, and Placebo
    TLDR
    No statistically significant differences in pain intensity or relief were seen for nefopam (Acupan), diphenhydramine (Benadryl), aspirin, or placebo despite a numerically higher score for ne fopam despite a unexpectantly high placebo response. Expand
    Nefopam in postoperative pain.
    TLDR
    Three comparable groups of surgical patients were given nefopam 0.4 mg kg-1 or morphine 0.15 mgkg-1 for pain relief after operation and produced no obvious cardiovascular or respiratory side-effects. Expand
    Rediscovery of Nefopam for the Treatment of Neuropathic Pain
    TLDR
    The recently discovered dual analgesic mechanisms of action, namely, descending pain modulation by triple neurotransmitter reuptake inhibition similar to antidepressants, and inhibition of long-term potentiation mediated by NMDA from the inhibition of calcium influx like gabapentinoid anticonvulsants or blockade of voltage-sensitive sodium channels like carbamazepine, enable NFP to be used as a therapeutic agent to treat neuropathic pain. Expand
    Nefopam: A Review of its Pharmacological Properties and Therapeutic Efficacy
    TLDR
    Nefopam is a non-narcotic analgesic not structurally related to other analgesic drugs, and when appropriate dose ratios were compared in short term studies it was shown to produce analgesia comparable to that with the oral analgesics aspirin, dextropropoxyphene and pentazocine, as well as that with ‘moderate’ doses of parenteral morphine, pethidine and pentacine. Expand
    A Comparison of the Analgesic Effect of Intramuscular Nefopam and Morphine in Patients with Postoperative Pain
    TLDR
    Nefopam is chemically Gasse13 recognized that the drug had an unrelated to any known class of analgesics analgesic effect in his human experimental and is pharmacologically distinct from model for muscle relaxant activity. Expand
    Oral nefopam and aspirin
    TLDR
    Treatment effects were consistent and indicative of good dose response to both active medications, and pain relief scores were more variable but were generally in accordance with SPID values. Expand
    A comparison of a new analgesic, nefopam hydrochloride, with morphine sulphate, pentazocine and pethidine hydrochloride in post-operative pain
    TLDR
    It is suggested that nefopam is a sufficiently potent analgesic agent to control post-operative pain, with a relatively low incidence of side-effects. Expand
    Comparison of the Analgesic Dose‐Effect Relationships of Nefopam and Oxycodone in Postoperative Pain
    TLDR
    Drowsiness and a decrease in the respiratory rate were the principal side‐effects of oxycodone, whereas tachycardia, restlessness, sweating and nausea were more frequent after nefopam. Expand
    Nefopam, a non-opioid analgesic, does not alleviate experimental work/effort dyspnoea in healthy humans: A randomised controlled trial.
    TLDR
    In this study, nefopam did not exhibit any effects on dyspnoea and was not studied as a control for Somaesthetic evoked potentials. Expand
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