Nalidixic Acid

Known as: Acido nalidixico, 1,8-Naphthyridine-3-carboxylic Acid, 1-ethyl-1,4-dihydro-7-methyl-4-oxo-, Acide nalidixique 
A synthetic quinolone and antibacterial agent with urinary tract antiseptic activity. Nalidixic acid concentrates in the renal tubules and bladder… (More)
National Institutes of Health

Papers overview

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Highly Cited
2007
Highly Cited
2007
Isolates of Salmonella enterica serovar Typhi that are multidrug resistant (MDR, resistant to chloramphenicol, ampicillin, and… (More)
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Highly Cited
2003
Highly Cited
2003
Fluoroquinolone use in poultry production may select for resistant Escherichia coli that can be transmitted to humans. To define… (More)
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Review
1999
Review
1999
Acquired antibiotic resistance, i.e. resistance genes located on conjugative or mobilizable plasmids and transposons can be found… (More)
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Highly Cited
1998
Highly Cited
1998
BACKGROUND Bacteria can mutate to acquire quinolone resistance by target alterations or diminished drug accumulation. Plasmid… (More)
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Review
1997
Review
1997
Multidrug resistance in bacteria is generally attributed to the acquisition of multiple transposons and plasmids bearing genetic… (More)
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Highly Cited
1996
Highly Cited
1996
Multiple-antibiotic-resistance (Mar) mutants of Escherichia coli are resistant to a wide variety of antibiotics, and increased… (More)
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Highly Cited
1986
Highly Cited
1986
DNA fragments of 3.4 kb containing the gyrB gene were cloned from Escherichia coli KL-16 and from spontaneous nalidixic acid… (More)
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Highly Cited
1977
Highly Cited
1977
ATP-dependent DNA supercoiling catalyzed by Escherichia coli DNA gyrase was inhibited by oxolinic acid, a compound similar to but… (More)
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Highly Cited
1977
Highly Cited
1977
A target protein for nalidixic and oxolinic acids in Escherichia coli, the nalA gene product (Pnal), was purified to homogeneity… (More)
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1964
1964
Goss, William A. (Sterling-Winthrop Research Institute, Rensselaer, N.Y.), William H. Dietz, and Thomas M. Cook. Mechanism of… (More)
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