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Nalidixic Acid

Known as: Acido nalidixico, 1,8-Naphthyridine-3-carboxylic Acid, 1-ethyl-1,4-dihydro-7-methyl-4-oxo-, Acide nalidixique 
A synthetic quinolone and antibacterial agent with urinary tract antiseptic activity. Nalidixic acid concentrates in the renal tubules and bladder… Expand
National Institutes of Health

Papers overview

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Review
2004
Review
2004
Acquired antibiotic resistance, i.e. resistance genes located on conjugative or mobilizable plasmids and transposons can be found… Expand
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Highly Cited
2003
Highly Cited
2003
ABSTRACT Fluoroquinolone use in poultry production may select for resistant Escherichia coli that can be transmitted to humans… Expand
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Highly Cited
1998
Highly Cited
1998
BACKGROUND Bacteria can mutate to acquire quinolone resistance by target alterations or diminished drug accumulation. Plasmid… Expand
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Highly Cited
1996
Highly Cited
1996
Multiple-antibiotic-resistance (Mar) mutants of Escherichia coli are resistant to a wide variety of antibiotics, and increased… Expand
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Highly Cited
1988
Highly Cited
1988
The fatty acid compositions and multiple antibiotic resistance patterns of 32 strains of Bradyrhizobium japonicum correlated with… Expand
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Highly Cited
1985
Highly Cited
1985
Norfloxacin is a nalidixic acid analogue and one of the most potent DNA gyrase inhibitors. To study the mechanism of this… Expand
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Highly Cited
1984
Highly Cited
1984
Many intercalative antitumor drugs have been shown to cleave DNA indirectly through their specific effect on the stabilization of… Expand
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Highly Cited
1979
Highly Cited
1979
Yeast extract (0.025%) and nalidixic acid (0.002%) were added to seawater samples and the samples were incubated for 6 h at 20… Expand
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Highly Cited
1977
Highly Cited
1977
ATP-dependent DNA supercoiling catalyzed by Escherichia coli DNA gyrase was inhibited by oxolinic acid, a compound similar to but… Expand
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Highly Cited
1977
Highly Cited
1977
A target protein for nalidixic and oxolinic acids in Escherichia coli, the nalA gene product (Pnal), was purified to homogeneity… Expand
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