M. Simpson

Publications69
h-index28
Citations2,391
Highly Influential Citations23
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Novel features of animal mtDNA evolution as shown by sequences of two rat cytochrome oxidase subunit II genes.
The sequence of the region of the mitochondrial genome that encodes cytochrome oxidase subunit II (COII) has been determined for each of two closely related rat species, Rattus norvegicus and R.… Expand
  • 142
  • 5
The PC12 cell as a model for studies of the mechanism of induction of peripheral neuropathy by anti-HIV-1 dideoxynucleoside analogs.
The ability of DNA polymerase gamma to utilize ddNTPs+ as substrates, incorporating these chain terminators into DNA (see citations in[1]), has led us to propose that AZT-induced bone marrow… Expand
  • 82
  • 4
Deoxyribonucleic acid biosynthesis in mitochondria. Purification and general properties of rat liver mitochondrial deoxyribonucleic acid polymerase.
Abstract Deoxyribonucleic acid polymerase has been purified 3550-fold from rat liver mitochondria, which computes to 14,000-fold based on whole liver as the starting material. The enzyme is… Expand
  • 90
  • 2
Intra- and interspecific variation of the mitochondrial genome in Rattus norvegicus and Rattus rattus: restriction enzyme analysis of variant mitochondrial DNA molecules and their evolutionary…
Restriction endonuclease analysis has revealed extensive mtDNA polymorphism in two species of rats, Rattus rattus and Rattus norvegicus. Sequence divergence values for the eight detected R.… Expand
  • 100
  • 2
Properties of Trypsin from the Pyloric Ceca of Atlantic Cod (Gadus morhua)
Trypsin (EC 3.4.21.4) was isolated from the pyloric ceca of Atlantic cod and purified to homogeneity by affinity chromatography. The enzyme catalyzed the hydrolysis of benzoyl arginine p-nitroanilide… Expand
  • 14
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The release of labeled amino acids from the proteins of rat liver slices.
  • M. Simpson
  • Medicine, Biology
  • The Journal of biological chemistry
  • 1 March 1953
  • 163
  • 1
Studies on the inhibition of mitochondrial DNA replication by 3'-azido-3'-deoxythymidine and other dideoxynucleoside analogs which inhibit HIV-1 replication.
  • 159
  • 1
Mitochondria contain a distinct DNA topoisomerase.
A topoisomerase (nicking-closing enzyme) has been isolated from rat liver mitochondria. It has purified by double-stranded DNA-cellulose chromatography approximately 50,000-fold, based on the crude… Expand
  • 44
  • 1
Deoxyribonucleic acid biosynthesis in mitochondria. Studies on the incorporation of labeled precursors into mitochondrial deoxyribonucleic acid.
Abstract Isolated rat liver mitochondria are capable of incorporating labeled deoxynucleoside triphosphates into DNA. The reaction is linear from 1 to 2 hours, is sensitive to high concentrations of… Expand
  • 35
  • 1
Effect of the bacterial DNA gyrase inhibitors, novobiocin, nalidixic acid, and oxolinic acid, on oxidative phosphorylation.
When incubated with isolated intact rat liver mitochondria, novobiocin and nalidixic acid act as uncouplers of oxidative phosphorylation; they stimulate oxygen uptake and inhibit ATP synthesis.… Expand
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