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Nafenopin

Known as: Propanoic acid, 2-methyl-2-(4-(1,2,3,4-tetrahydro-1-naphthalenyl)phenoxy)-, Nafenopin [Chemical/Ingredient], Acid, Nafenoic 
A peroxisome proliferator that is used experimentally to promote liver tumors. It has been used as an antihyperlipoproteinemic agent.
National Institutes of Health

Related topics

Related topics

11 relations

Narrower (2)

CH-13437SU-13,437

Broader (2)

Hypolipidemic AgentsPeroxisome Proliferators
In Bloodagonistsanalogs & derivativesantagonists & inhibitors

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
1990
1990
Peroxisome proliferation and modulation of rat liver carcinogenesis by 2,4-dichlorophenoxyacetic acid, 2,4,5-trichlorophenoxyacetic acid, perfluorooctanoic acid and nafenopin.
Using an initiation--selection--promotion protocol for induction of liver tumors in Wistar rats, the modulating action of various… 
Highly Cited
1990
Highly Cited
1990
Effects of hypolipidemic drugs nafenopin and clofibrate on phenotypic expression and cell death (apoptosis) in altered foci of rat liver.
Phenotypically altered liver foci were produced in female Wistar rats by a single dose of N-nitrosomorpholine followed by… 
Highly Cited
1989
Highly Cited
1989
Differential induction and regulation of peroxisomal enzymes: predictive value of peroxisome proliferation in identifying certain nonmutagenic carcinogens.
1988
1988
Induction of hepatic peroxisome proliferation in mice by lactofen, a diphenyl ether herbicide.
1986
1986
Comparative analysis of the effect of phenobarbital, dichlorodiphenyltrichloroethane, butylated hydroxytoluene and nafenopin on rat hepatocarcinogenesis.
In order to investigate whether different 'promoters' have the same qualitative and/or quantitative effects on rat… 
Highly Cited
1984
Highly Cited
1984
Effect of hypolipidemic peroxisome proliferators on unscheduled DNA synthesis in cultured hepatocytes and on mutagenesis in Salmonella.
Highly Cited
1984
Highly Cited
1984
Inhibitory effect of nafenopin upon the development of diethylnitrosamine-induced enzyme-altered foci within the rat liver.
The effect of nafenopin and phenobarbitone upon the distribution of gamma-glutamyltranspeptidase activity and epoxide hydrolase… 
Highly Cited
1983
Highly Cited
1983
Peroxisome proliferation in primary cultures of rat hepatocytes.
1983
1983
Carnitine octanoyltransferase of mouse liver peroxisomes: properties and effect of hypolipidemic drugs.
Highly Cited
1977
Highly Cited
1977
The peroxisome proliferation-associated polypeptide in rat liver.
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