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Nafenopin

Known as: Propanoic acid, 2-methyl-2-(4-(1,2,3,4-tetrahydro-1-naphthalenyl)phenoxy)-, Nafenopin [Chemical/Ingredient], Acid, Nafenoic 
A peroxisome proliferator that is used experimentally to promote liver tumors. It has been used as an antihyperlipoproteinemic agent.
National Institutes of Health

Related topics

Related topics

11 relations

Narrower (2)

CH-13437SU-13,437

Broader (2)

Hypolipidemic AgentsPeroxisome Proliferators
In Bloodagonistsanalogs & derivativesantagonists & inhibitors

Papers overview

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1997
1997
Inhibition instead of enhancement of lipid peroxidation by pretreatment with the carcinogenic peroxisome proliferator nafenopin in rat liver exposed to a high single dose of corn oil
Abstract Oxidative stress is discussed as a possible hepatocarcinogenic mechanism of peroxisome proliferators (PP) in rodents and… 
1995
1995
Species differences in the clonal expansion of hepatocytes in response to the coaction of epidermal growth factor and nafenopin, a rodent hepatocarcinogenic peroxisome proliferator.
Peroxisome proliferators are members of the nongenotoxic family of rodent hepatocarcinogens. There exist substantial species… 
1986
1986
Effects of the hypolipidemic drug nafenopin on the zona glomerulosa of the rat adrenal cortex: morphological counterparts of functional alterations.
The effects of nafenopin, a hypolipidemic drug, on the zona glomerulosa of the rat adrenal cortex were investigated. Chronic… 
1986
1986
Effect of nafenopin, a peroxisome proliferator, on energy metabolism in the rat as a function of acclimation temperature
The effects of the peroxisome proliferator, nafenopin, on body temperature, apparent gross food efficiency and activity of… 
Highly Cited
1984
Highly Cited
1984
The effect of hypolipidaemic agents on peroxisomal beta-oxidation and mixed-function oxidase activities in primary cultures of rat hepatocytes. Relationship between induction of palmitoyl-CoA…
A study was conducted of the effects of 10 hypolipidaemic agents on peroxisomal and microsomal enzyme activities in primary… 
1978
1978
A study on cerium-induced liver injury in rats after pretreatment with spironolactone, phenobarbital, pregnenolone-16 alpha-carbonitrile and nafenopin.
A number of drugs known to induce liver microsomal enzymes were studied with respect to their effect on the elevated liver… 
1976
1976
Differences in liver weight, mortality in cerium-treated mice and 144Ce levels in blood, liver, urine and faeces at various intervals after treatment with nafenopin and pregnenolone 16-alpha…
Pretreatment with nafenopin and pregnenolone-16-alpha-carbonitrile (PCN) decreased the acute lethal toxicity in mice induced by… 
1976
1976
Drug metabolism and morphologic changes in the liver of nafenopin-treated rats.
Nafenopin (2-methyl-2[p-(1,2,3,4-tetrahydro-1-naphthyl) phenoxy] propionic acid), a phenolic ether with hypolipidemic properties… 
1971
1971
Growth and luteinizing hormone decreases during nafenoic acid therapy.
1971
1971
Changes in liver and spleen scans of patients during treatment with two hypolipidemic drugs.
Abstract Liver and spleen scans using 99mTc-labeled sulfur colloid were performed in 5 patients with hyperlipoproteinemia at the…