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NQO1*2 Allele

Known as: NAD(P)H Dehydrogenase, Quinone 1*2 Allele, NQO1*2, NQO1 C609T 
Human NQO1*2 allele is located in the vicinity of 16q22.1 and is approximately 17 kb in length. The NQO1 *2 allele has a C609T substitution in the… 
National Institutes of Health

Related topics

Related topics

8 relations
16q22.1Cytosine to Thymidine Transition AbnormalityDecreased Biochemical ActivityMetabolic Detoxication, Drug

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2009
Highly Cited
2009
Acquired resistance to 17-allylamino-17-demethoxygeldanamycin (17-AAG, tanespimycin) in glioblastoma cells.
Heat shock protein 90 (HSP90) inhibitors, such as 17-allylamino-17-demethoxygeldanamycin (17-AAG, tanespimycin), which is… 
Review
2008
Review
2008
NQO1 polymorphisms and de novo childhood leukemia: a HuGE review and meta-analysis.
Polymorphisms in NQO1, a gene coding for the phase II enzyme involved in the detoxification of quinone carcinogens, have been… 
Highly Cited
2007
Highly Cited
2007
Profile of polymorphisms of drug‐metabolising enzymes and the risk of therapy‐related leukaemia
Therapy‐related acute myeloid leukaemia/myelodysplastic syndrome (t‐AML/t‐MDS) results from an impaired ability to detoxify… 
Highly Cited
2007
Highly Cited
2007
The potential effect of gender in combination with common genetic polymorphisms of drug-metabolizing enzymes on the risk of developing acute leukemia.
BACKGROUND AND OBJECTIVES We examined common polymorphisms in the genes for glutathione S-transferase (GST), cytochrome P450 (CYP… 
Highly Cited
2007
Highly Cited
2007
Genetic polymorphisms and benzene metabolism in humans exposed to a wide Range of air concentrations
Using generalized linear models with natural-spline smoothing functions, we detected effects of specific xenobiotic metabolizing… 
Highly Cited
2005
Highly Cited
2005
CYP1A1 and CYP1B1 polymorphisms and risk of lung cancer among never smokers: a population-based study.
The cytochrome P450 (CYP) superfamily of enzymes catalyse one of the first steps in the metabolism of carcinogens such as… 
Highly Cited
2003
Highly Cited
2003
NQO1 C609T polymorphism associated with esophageal cancer and gastric cardiac carcinoma in North China.
AIM To investigate the association of the NQO1 (C609T) polymorphism with susceptibility to esophageal squamous cell carcinoma… 
Review
2002
Review
2002
NAD(P)H:quinone oxidoreductase (NQO1) polymorphism, exposure to benzene, and predisposition to disease: A HuGE review
NAD(P)H:quinone oxidoreductase (NQO1) catalyzes the two- or four-electron reduction of numerous endogenous and environmental… 
Highly Cited
2002
Highly Cited
2002
Low NAD(P)H:quinone oxidoreductase activity is associated with increased risk of leukemia with MLL translocations in infants and children.
An inactivating polymorphism at position 609 in the NAD(P)H:quinone oxidoreductase 1 gene (NQO1 C609T) is associated with an… 
Highly Cited
1998
Highly Cited
1998
NAD(P)H:quinone oxidoreductase: polymorphisms and allele frequencies in Caucasian, Chinese and Canadian Native Indian and Inuit populations.
NAD(P)H:quinone oxidoreductase (NQO1) catalyses the two-electron reduction of quinone compounds. NQO1 is involved in the… 
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