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NAD(P)H:quinone oxidoreductase 1 (NQO1): chemoprotection, bioactivation, gene regulation and genetic polymorphisms.
TLDR
This review focuses on detoxification reactions catalyzed by NQO1 and its role in antioxidant defense via the generation of antioxidant forms of ubiquinone and vitamin E. Expand
NAD(P)H:quinone oxidoreductase 1 (NQO1) in the sensitivity and resistance to antitumor quinones.
TLDR
The role of NQO1 in the sensitivity and resistance of human cancers to the quinone antitumor drugs mitomycin C, β-lapachone and the benzoquinone ansamycin class of Hsp90 inhibitors including 17-AAG is discussed. Expand
NAD(P)H:Quinone oxidoreductase activity is the principal determinant of beta-lapachone cytotoxicity.
TLDR
It is demonstrated that the enzyme NAD(P)H:quinone oxidoreductase (NQO1) substantially enhances the toxicity of beta-lapachone, and this is the first definitive elucidation of an intracellular target for beta- Lapachone in tumor cells. Expand
NAD(P)H:quinone oxidoreductase 1: role as a superoxide scavenger.
TLDR
NQO 1 can generate hydroquinones that are redox active, and the O(2)(*)(-) scavenging activity of NQO1 may provide an additional level of protection against O( 2)(*)*)(-) induced toxicity. Expand
NAD(P)H:quinone oxidoreductase 1 (NQO1, DT-diaphorase), functions and pharmacogenetics.
TLDR
The chapter summarizes the role of NQO1 in chemoprotection and its contrasting role in bioactivation of antitumor quinines, the relevance of the common NZO1 polymorphism for chemoprotsection, susceptibility to disease and cancer chemotherapy, and current information on polymorphic forms of N QO1. Expand
Association of NAD(P)H: quinone oxidoreductase 1 (NQO1) C609T polymorphism with esophageal squamous cell carcinoma in a German Caucasian and a northern Chinese population.
TLDR
The association of the NQO1 C609T polymorphism with ESCC in genetically distinct populations makes a strong argument for its importance in carcinogenesis of ES CC in the German Caucasian and the northern Chinese population. Expand
Metabolism of mitomycin C by DT-diaphorase: role in mitomycin C-induced DNA damage and cytotoxicity in human colon carcinoma cells.
TLDR
The data suggest that two-electron reduction of mitomycin C by DT-diaphorase may be an important determinant of mitomecin C-induced genotoxicity and cytotoxicity. Expand
NAD(P)H:Quinone Oxidoreductase Activity Is the Principal Determinant of β-Lapachone Cytotoxicity*
TLDR
It is demonstrated that the enzyme NAD(P)H:quinone oxidoreductase (NQO1) substantially enhances the toxicity of β-lapachone, and this is the first definitive elucidation of an intracellular target for β- Lapachone in tumor cells. Expand
Formation of 17-allylamino-demethoxygeldanamycin (17-AAG) hydroquinone by NAD(P)H:quinone oxidoreductase 1: role of 17-AAG hydroquinone in heat shock protein 90 inhibition.
TLDR
Low-performance liquid chromatography analysis of the metabolism of 17-AAG by recombinant human NQO1 revealed the formation of a more polar metabolite17-AAGH2, a relatively stable hydroquinone that exhibits superior Hsp90 inhibition. Expand
The reduction of alpha-tocopherolquinone by human NAD(P)H: quinone oxidoreductase: the role of alpha-tocopherolhydroquinone as a cellular antioxidant.
TLDR
The ability of human NAD(P)H:quinone oxidoreductase (NQO1) to catalyze the reduction of TQ to TQH2 in cell-free and cellular systems is examined and it is demonstrated that TQ is reduced more efficiently than coenzyme Q10 and that T QH2 can function as an efficient antioxidant. Expand
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