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Nrf2 enhances resistance of cancer cells to chemotherapeutic drugs, the dark side of Nrf2.
Drug resistance during chemotherapy is the major obstacle to the successful treatment of many cancers. Here, we report that inhibition of NF-E2-related factor 2 (Nrf2) may be a promising strategy to… Expand
Redox-directed cancer therapeutics: molecular mechanisms and opportunities.
- G. Wondrak
- Medicine, Biology
- Antioxidants & redox signaling
- 4 November 2009
Redox dysregulation originating from metabolic alterations and dependence on mitogenic and survival signaling through reactive oxygen species represents a specific vulnerability of malignant cells… Expand
Therapeutic Potential of Nrf2 Activators in Streptozotocin-Induced Diabetic Nephropathy
OBJECTIVE To determine whether dietary compounds targeting NFE2-related factor 2 (Nrf2) activation can be used to attenuate renal damage and preserve renal function during the course of… Expand
Endogenous UVA-photosensitizers: mediators of skin photodamage and novel targets for skin photoprotection.
- G. Wondrak, M. Jacobson, E. Jacobson
- Chemistry, Medicine
- Photochemical & photobiological sciences…
- 7 February 2006
Endogenous chromophores in human skin serve as photosensitizers involved in skin photocarcinogenesis and photoaging. Absorption of solar photons, particularly in the UVA region, induces the formation… Expand
Identification of α-dicarbonyl scavengers for cellular protection against carbonyl stress
Abstract Tissue deterioration and aging have long been associated with the accumulation of chemically induced protein and DNA damage. Reactive oxygen species (ROS) and reactive carbonyl species… Expand
An Essential Role of NRF2 in Diabetic Wound Healing
The high mortality and disability of diabetic nonhealing skin ulcers create an urgent need for the development of more efficacious strategies targeting diabetic wound healing. In the current study,… Expand
Resveratrol prevents epigenetic silencing of BRCA-1 by the aromatic hydrocarbon receptor in human breast cancer cells.
- A. Papoutsis, Sarah D. Lamore, G. Wondrak, Ornella I Selmin, D. F. Romagnolo
- Biology, Medicine
- The Journal of nutrition
- 1 September 2010
The BRCA-1 protein is a tumor suppressor involved in repair of DNA damage. Epigenetic mechanisms contribute to its reduced expression in sporadic breast tumors. Through diet, humans are exposed to a… Expand
The antimalarial amodiaquine causes autophagic-lysosomal and proliferative blockade sensitizing human melanoma cells to starvation- and chemotherapy-induced cell death
Pharmacological inhibition of autophagic-lysosomal function has recently emerged as a promising strategy for chemotherapeutic intervention targeting cancer cells. Repurposing approved and abandoned… Expand
Pentoses and Hexoses as Sources of New Melanoidin-like Maillard Polymers
N-Substituted pyrroles (1), 2-furaldehyde (2), and N-substituted 2-formylpyrroles (3), formed in pentose (hexose) Maillard systems, were identified as components of extraordinary polycondensation… Expand
The Nrf2-inducers tanshinone I and dihydrotanshinone protect human skin cells and reconstructed human skin against solar simulated UV☆
Exposure to solar ultraviolet (UV) radiation is a causative factor in skin photocarcinogenesis and photoaging, and an urgent need exists for improved strategies for skin photoprotection. The… Expand